Disease Information for Lennox-Gastaut syndrome/epilepsy

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Clinical Manifestations
Signs & Symptoms
Abnormal movements/involuntary
Mental Deficiency Child
Myoclonus/Myoclonic jerks on exam
Seizures/Children/recurrent
Disease Progression
Course/Acute
Course/Chronic disease crisis/flare/attacks
Course/Chronic disorder
Course/Paroxysmal
Course/Recurrent
Course/Recurrent illness pattern
Course/Relapsing
Seizures unresponsive to treatment
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Diagnostic Test Results
Electrodiagnosis
EEG/Abnormality
EEG/Seizure activity abnormality
EEG/Slow Spike Wave Pattern
Associated Diseases & Rule outs
Associated Disease & Complications
Epilepsy
Mental retardation
Seizure disorder (epilepsy)
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Epileptic encephalopathy
Pathophysiology/Epileptiform/epileptic disorder
Process
PROCESS/Eponymic (category)
PROCESS/Use/Age/atrophic disorder (category)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Synonyms
Synonym
Gastaut syndrome, Lennox Gastaut, Lennox Gastaut syndrome, Lennox Gastaut syndrome (disorder), Lennox Gestaut syndrome, Synonym/LGS Seizure Disorder, Synonym/Spike Wave Stupor
Treatment
Drug Therapy - Indication
RX/Anticonvulsants
RX/Clobazam (Onfi)
RX/Felbamate (Felbatol)
RX/Rufinamide (Banzel)
Definition

Lennox Gastaut Syndrome; LGS; Lennox-Gastaut Syndrome (LGS) is a rare disorder that typically becomes apparent during infancy or early childhood; The disorder is characterized by frequent episodes of uncontrolled electrical disturbances in the brain (seizures) and, in many cases, abnormal delays in the acquisition of skills that require the coordination of mental and muscular activity (psychomotor retardation); Individuals with the disorder may experience several different types of seizures; Lennox-Gastaut Syndrome may be due to or occur in association with a number of different underlying disorders or conditions--- [nord 2005]--------------------------------

Lennox-Gastaut; Doose’s syndrome; Gastaut"s syndrome II;

Lennox’ encephalopathy; Lennox’ syndrome; Lennox’ variant;

Astatic petit mal syndrome; hemiconvulsion-hemiplegia-epilepsy syndrome, petit mal variant; A common epileptic syndrome which usually commences before the age of 6 with myoclonic seizures by day and tonic seizures at night, with atypical absences, head nodding, and drop attacks particularly prominent; Unconsciousness, epigastric, pharyngeal, or abdominal aura, a sensation of fear, and sucking movements are symptoms; Cerebral edema and injuries are the suspected causes; It often has a poor prognosis with progressive mental deterioration; Lennox-Gastaut seizures are so powerful and occur so frequently – as often as 200 times an hour – that mental retardation is generally unavoidable; Doose"s syndrome (when strong genetic basis) is entered as a separate entity--------------[whonamedit_com 2005]-----------------

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External Links Related to Lennox-Gastaut syndrome/epilepsy
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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