Disease Information for Lathyrism

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Clinical Manifestations
Signs & Symptoms
Teeth malformed/dysplastic
Unerupted teeth
Muscle Pain
Muscle weakness
Myalgias
Tender or painful muscles/Myalgias
Thigh muscle weakness
Hyperesthesia
Paralysis
Paresthesias
Spastic paralysis/signs
Spastic paraplegia/signs
Spasticity/Spastic gait
Unable to walk
Weak lower extremities
Acute Back Pain
Back Pain
Backache
Joint range of motion/excess
Unable to stand
Clinical Presentation & Variations
Presentation/Epidemic poisoning Food Community Situation
Disease Progression
Course/Chronic disorder
Course/Prognosis bad/usually
Onset/Acute/Course chronic
Demographics & Risk Factors
Exposure Factors
Exposure/African horse sickness
Exposure/Cattle sick/Fodder toxin
Travel, Geographic & Climate Related Factors
Residence/travel/Bangladesh
Residence/travel/Ethiopia
Residence/travel/India
Residence/travel/Spain
Established Disease Population
Patient/Malnourished/starved
Population Group
Population/Poverty/Low socioeconomic patient
Event, Activity, Behavioral & Seasonal Factors
Event/Community clusters/family members also ill
Event/Disaster situation
Event/Mass exposure/community illness/death
Event/Warfare/Combat status/effects
Sex & Age Groups
Population/Adult ('twenties')
Population/Adult/all
Population/Male
Diagnostic Test Results
Pathology
PATH/Gliosis spinal cord
Associated Diseases & Rule outs
Rule Outs
Adult Copper Deficiency Myelopathy
Copper deficiency/deficit
Fish poisoning neuropathic syndrome
Associated Disease & Complications
Abdominal aortic aneurysm
Kyphoscoliosis
Kyphosis
Lathyrism/legume toxicity
Paraplegia
Paraplegia, spastic
Plant poisoning/accidental
Skeletal/bone malformations
Subluxations
Teeth enamel hypoplastic
Thoracic aneurysm/dilated aorta/ectasia
Disease Mechanism & Classification
Pathophysiology
Pathophysiology/Toxic inhibition lysyl oxidase effect
Pathophysiology/Mitochondrial lesion
Process
PROCESS/Poison/specific (category)
Toxin
TOXIN/B-Aminopropriononitrile/effect
TOXIN/Plant Contains multiple toxins
TOXIN/Poison/Botanical/alkaloids/plant toxins (category)
Treatment
Drug Therapy - Indication
RX/No treatment
RX/No Treatment needed/usually symptomatic only
Drug Dosage
DRUG-Herbal Famine food history
Other Treatments
TX/Avoidance offending agents (indication).
Definition

A paralytic condition of the legs caused by ingestion of lathyrogens, especially beta-aminopropionitrile, found in the seeds of plants of the genus Lathyrus (see FABACEAE).

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External Links Related to Lathyrism
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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