Disease Information for Larsen Dysmorphic Syndrome

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Clinical Manifestations
Signs & Symptoms
Particular physiognomy/Odd looking kids
Facies particular
Low Nasal Bridge
Webbed neck deformity/Broad neck
Nails hypoplastic/dysplastic
Short fingernails
Small nails/congenital
Cylindrical Fingers/Congenital
Intelligence normal
Hyperextensible joints Laxity Instability
Joint range of motion/excess
Knee Pain
Short stature
Short stature Child
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Family History
Family history/Skeletal malformations
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Population/Male
Associated Diseases & Rule outs
Associated Disease & Complications
Brachycephaly
Cleft palate/deformity
Clubbed foot/congenital
Dwarfism
Facial dysplasia
Hip dislocation, congenital
Hypermobility joints syndrome
Larsen dysmorphic syndrome
Mental retardation
Multiple Congenital Anomalies
Multiple Congenital Dislocations
Shoulder dislocation
Skeletal dysplasia
Subluxations
Vertebrae Anomalies
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Skeletal (category)
CLASS/Systemic/no comment (category)
Process
PROCESS/Autosomal dominant hereditary disease (ex).
PROCESS/Autosomal recessive disorder (ex)
PROCESS/Congenital/developmental (category)
PROCESS/Eponymic (category)
PROCESS/Genetic expressivity variable (ex)
PROCESS/Hereditofamilial (category)
PROCESS/INCIDENCE/Esoteric disease (example)
PROCESS/Anomalies/Deformities/Malformations (EX)
Synonyms
Synonym
Autosomal Dominant Larsen Syndrome, Synonym/Desbuquois syndrome, Synonym/Larsen multiple dislocation/dysmorphic syndrome
Definition

Larsen Syndrome; Desbuquois Syndrome; Joint dislocations/unusual facies/skeletal abnormalities; Multiple joint dislocations, Larson-like; Skeletal abnormalities/joint dislocations/unusual facies; Larsen syndrome is a rare genetic disorder in which associated features may vary greatly in range and severity from case to case. However, primary features may include multiple joint dislocations; foot deformities; non-tapering, cylindrically shaped fingers; and/or an unusual facial appearance. In some cases, additional features may be present, such as short stature, additional skeletal abnormalities, incomplete closure of the roof of the mouth (cleft palate), heart defects, hearing impairment, mental retardation, and/or other abnormalities [NORD 2005]---------------------------

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External Links Related to Larsen Dysmorphic Syndrome
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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