Disease Information for Laronidase (Aldurazyme/Alpha-Iduronidase)

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Clinical Manifestations
Signs & Symptoms
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Drug fever
Disease Mechanism & Classification
Drugs
DRUG/ Source rDNA Manufacture
DRUG/Enzyme replacement drug/Metabolic disease
DRUG/Genetically engineered/biological drug (example)
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
alpha L Idosiduronase, alpha L Iduronidase, Alpha L iduronidase (substance), Glycosaminoglycan alpha L iduronohydrolase, Iduronidase, L iduronidase, L Iduronidase (substance), Brand name/Aldurazyme (MPS I enzyme)
Treatment
Drug Dosage
DRUG/.$$$$ Very Expensive
DRUG/Infusion option medication
DRUG/Intravenous administraton RX
DRUG/Intravenous only RX
DRUG/Orphan/One indication drug (ex)
Definition

Human alpha-L-Iduronidase injection 2.9 mgm for specific mucopolysaccharide type one patients; this is MPS-I Hurlers,Scheie,and Hurlers-Scheie syndromes with severe symptoms; orphan drug very expensive

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External Links Related to Laronidase (Aldurazyme/Alpha-Iduronidase)
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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