Disease Information for Lactic acidosis

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Clinical Manifestations
Signs & Symptoms
Nausea
Vomiting
Altered Mental State Diabetic
Altered mental status Mental status change
Drowsiness/somnolence
Infant Seizures
Obtunded/poorly responsive status/signs
Seizures/Children/recurrent
Stupor/poor reponse to stimulus
Sudden unconsciousness
Air hunger of Kussmal
Hyperpnea
Rapid Breathing
Respiratory distress
Tachypnea/Increased respiratory rate
Debilitated
Typical Clinical Presentation
Stroke syndrome kids/metabolic causes
Clinical Presentation & Variations
Presentation/Non diabetic Ketoacidosis Kids infants
Disease Progression
Course/Acute
Course/Acute only
Course/Lethal
Course/Severe illness
Demographics & Risk Factors
Established Disease Population
Patient/Alcoholism/chronic alcoholic
Patient/Moribund/terminal
Patient/Shock status
Laboratory Tests
Abnormal Lab Findings (Non Measured)
URINE Alkaline
Abnormal Lab Findings (Non Measured)
Lactate/pyruvate ratio high (plasma) (Lab)
Osmotic gap (low Na/high osmolality) (Lab)
Plasma lactate/chilled collection abnormal (Lab)
Abnormal Lab Findings - Decreased
Bicarbonate, serum (Lab)
Carbon Dioxide Total Content/CO2
Ketones, plasma (Lab)
PCO2, arterial blood (Lab)
pH, arterial blood (Lab)
URINE PH
Abnormal Lab Findings - Increased
Anion gap (Lab)
Lactic acid/Lactate (Lab)
Phosphate Serum (Lab)
Associated Diseases & Rule outs
Rule Outs
Diabetic ketoacidosis/coma
Ketoacidosis non diabetic
Propofol Infusion Syndrome (PRIS)
Reye's syndrome
Associated Disease & Complications
Acidosis
Acidosis, metabolic
Coma in Children
Coma/Unconscious
Hyperphosphatemia
Hyperventilation
Hypochloremic metabolic alkalosis
Lactic acidosis
Metabolic Acidosis with High Anion Gap
Metabolic encephalopathy
Primary lactic acidemias
Disease Synergy - Causes
Synergy/Congestive heart failure
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
Pathophysiology
Pathophysiology/Perfusion defect/systemic
Pathophysiology/Hyperventilation Persistent Drive
Process
PROCESS/Biochemical (category)
PROCESS/Water/electrolyte balance disorder
Treatment
Drug Therapy - Indication
RX/Bicarbonate
RX/Diechloracetate (?)
RX/Oxygenated Pegylated Hgb (MP4OX)
Other Treatments
TX/Hemodialysis.
Definition

Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as diabetes mellitus, leukemia, or liver failure.

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External Links Related to Lactic acidosis
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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