Disease Information for Kyasanur forest disease

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Clinical Manifestations
Signs & Symptoms
Low Blood Pressure
Tachycardia/Fast heart rate
Bleeding from venipuncture sites/needle stick
Bruising/Ecchymosis
Convalescent Desquamation palms/soles
Erythematous generalized rash
Facial erythema
Facial flushing/Beet red
Fever and Rash
Flushing
Hemorrhagic rash
Hemorrhagic/Confluent ecchymotic rash
Macular rash
Non-pruritic rash
Petechiae/Petechial rash
Rash
Rash, macular/maculopapular or morbilliform
Acute spontaneous/widespread bleeding/signs
Bleeding from all orifices
Excessive/easy bruising tendency
Bleeding from mouth/oral blood
Bleeding gums
Lymphadenopathy Systemic
CNS symptoms/signs
Confusion/Disoriented
Arthritis with Fever
Arthritis with rash/dermatitis
Acutely ill patient/signs
Fever
Fever Febrile Possible
Fever, high
Flu-Like Syndrome
High body temperature
Toxic and Febrile Septic
Bleeding from eyes
Dimming vision/acute
Clinical Presentation & Variations
Presentation/Fever Rash Prostration Abrupt
Presentation/Eye Oral GI GU Hemorrhage
Disease Progression
Course/Acute
Course/Acute only
Course/Biphasic pattern/untreated
Course/Untreated mortality high
Demographics & Risk Factors
Exposure Factors
Exposure/Terrorist biologic weapon agents
Exposure/Terrorist/Chemical-biological weapon (CBW)
Travel, Geographic & Climate Related Factors
Residence/travel/India
Ethnic or Racial Factors
Asian Indian population
Population Group
Population/Immigrant population
Event, Activity, Behavioral & Seasonal Factors
Event/Mass exposure/community illness/death
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Renal function abnormalities (Lab)
Right Shift (Viral) Differential Smear (Lab)
Abnormal Lab Findings - Increased
D Dimer Levels (Lab)
Platelet count (Lab)
Prothromin Fragments
Associated Diseases & Rule outs
Rule Outs
Bolivian Hemorrhagic Fever/Machupo
Dengue hemorrhagic fever
Ebola virus/disease
Lassa fever
Yellow fever
Associated Disease & Complications
Bleeding diathesis/hemorrhagic diathesis
Bleeding Tendency
Encephalitis, secondary
Epistaxis/nosebleed
Hemorrhagic fever syndrome
Hyperpyrexia
Hypotension
Meningoencephalitis
Retinitis
Thrombocytopenia
Thrombocytosis
Tick-borne hemorrhagic fevers
Viral hemorrhagic fevers
Disease Mechanism & Classification
Specific Agent
AGENT/Aerosolized bioterror weapon
AGENT/Endemic disease (ex)
AGENT/Flavivirus (Arbovirus group B) (ex)
AGENT/Person to person spread/NOT usual
AGENT/Single stranded DNA virus
AGENT/Tick transmitted viral illness
AGENT/Tick-borne illness (ex)
AGENT/Virus (category)
AGENT/Virus hemorrhagic/vasculitic rash usual
AGENT/Virus kills cells/cytotoxic
Pathophysiology
Pathophysiology/Infectious vasculitis/capillaritis
Process
PROCESS/INCIDENCE/Regional specific
PROCESS/Infection/agent specific (category)
Toxin
TOXIN/CBRNE (Chemical/Biologic Weapons All) potential
Treatment
Other Treatments
TX/Expectant/supportive treatment.
Definition

Tick-borne flavivirus infection occurring in the Kyasanur Forest in India; 3-8 day incubation; major encephalitis, minor hemorrhagic and liver involvent, absent nephropathy;------------------------------

TICK-BORNE HEMORRHAGIC FEVERS Kyasanur Forest disease and Omsk hemorrhagic fever are tick-borne flavivirus infections that are seasonally transmitted in the areas of southern and central India and Siberia; Kyasanur Forest disease occurs mainly among villagers and lumbermen with forest contact, and Omsk hemorrhagic fever is transmitted directly from infected muskrats (as well as ticks) and may also be waterborne; These are self-limited illnesses characterized by acute fever and chills, myalgia, headache, vomiting, and diarrhea lasting 4 to 10 days in half of all cases, and hypotension, which can persist for several days; Hemorrhages tend to be minor in Omsk hemorrhagic fever and are present from the onset of illness; Neurologic signs, including depressed consciousness, neck stiffness, tremor, rigidity, pyramidal signs, and convulsions, appear in 50% of Kyasanur Forest disease cases, but are less prominent in Omsk hemorrhagic fever; Hepatitis and acute renal failure are components of both illnesses, and bronchitis, pneumonia, and hemorrhagic pulmonary edema develop in 40% of cases; fatalities are rare; [Rudolph"s Pediatrics 2002]-------------------------------------A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus; incubation 2-9 days;major hemorrhagic and liver involvement, minor encephalitis, absent nephropathy;-------------------------------------------- CRIMEAN-CONGO HEMORRHAGIC FEVER Crimean-Congo hemorrhagic fever is a serious tick-borne and potentially fatal illness that is acquired directly from tick bites or from contact with or aerosol transmission by blood from infected animals, but this disease also poses a significant threat for nosocomial transmission; Onset is usually abrupt with severe headache, high fever, myalgia, weakness, anorexia, back and abdominal pain, and nausea often accompanied by vomiting; There is hyperemia, which is most notable on the face, mucous membranes, and upper part of the body; The illness generally has a biphasic course: early nonspecific symptoms are followed after the sixth day of illness by hemorrhage from the nose, mouth, and gastrointestinal tract, and the appearance of large ecchymotic areas on the limbs; Most cases are apathetic or obtunded with halting speech; dizziness and mild meningeal signs are common; Elevated bilirubin and liver enzyme levels are usually present; Severe cases are delirious or comatose, and death is the consequence of circulatory collapse and disseminated intravascular coagulation -------[Rudolph"s Pediatrics 2002]---------

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NEJM (The New England Journal of Medicine)
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