Disease Information for Korsakoff's psychosis/Alcohol dementia

Clinical Manifestations
Signs & Symptoms
Alcohol facies
Failure to Thrive
Malnourished/poor nutrition status/signs
Alcohol on breath/odor of alcohol
Agnosognosia (Insite/awareness failure)
Altered mental status Mental status change
Amnesia/event, retrograde/antegrade
Behavior problems
Blackouts/Event amnesia/temporary
Cognitive defect
Executive function loss/apathy/inertia
Gait disturbance/abnormality
Hand tremors
Memory Loss in Elderly
Near recall/memory deficit/defect
Paucity of ideas/conversation
Personality change
Rapidly progressive dementia
Short term memory loss
Slurred speech
Slurred speech/Chronic
Stupor/poor reponse to stimulus
Sudden unconsciousness
Tremor in Elderly
Behavior/life plans erratic
Destructive Behavior
Poverty of thought
Scattered thought process
Failure to Thrive/Adult
Disease Progression
Course/Chronic disorder
Course/Prognosis bad/usually
Demographics & Risk Factors
Established Disease Population
Patient/Alcoholism/chronic alcoholic
Patient/Excess alcohol habit
Population Group
Aged Adult
Sex & Age Groups
Population/Adult Aged Only
Population/Man patient
Population/Middle-aged adult
Laboratory Tests
Abnormal Lab Findings - Decreased
RBC Transketolase activity (LAB)
Thiamine/Vitamin B1 (Lab)
URINE Thiamine
Abnormal Lab Findings - Increased
CDT [Carbohydrate-Deficience Transferrin test]/Abnormal
Ethanol blood level/toxin (Lab)
Pyruvate, plasma (Lab)
Diagnostic Test Results
PATH/Brain Mammillary bodies defect/lesion
PATH/Brain Medial thalamus lesion
PATH/Brain/Glial proliferation/ganglion cell lysis
CT Scan
MRI/Head Mammillary Body lesions
MRI/Head/Medial Thalamus Lesion
Associated Diseases & Rule outs
Rule Outs
Creutzfeld-Jacob disease
Hepatic encephalopathy
Associated Disease & Complications
Alcohol dementia
CNS disease/involvement
Hypothalamic lesion
Korsakoff Psychosis/Alcohol Dementia
Neurobehavior Problems
Organic brain syndrome
Secondary Psychosis/Symptomatic
Sedation/torpor induced
Demyelinating Disease
Disease Synergy - Causes
Risk factor/Alcoholism
Disease Mechanism & Classification
CLASS/Limbic System Lesion/Defect
CLASS/Neurologic (category)
Pathophysiology/Mammillary bodies/lesion
Pathophysiology/Thiamine/pyrophosphate neurol metab
PROCESS/Poison/specific (category)
PROCESS/Psychoses disorder (ex)
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Drug Therapy - Indication
Other Treatments
TX/Discontinue Toxin/Abuse

Korsakoff"s psychosis and syndrome; Korsakoff"s disease;

Korsakoff’s psychosis; Korsakoff’s symptom complex;

Meynert’s amentia; Amnestic confabulatory syndrome, amnestic syndrome, cerebropathia psychica toxemica, polyneuritic psychosis, psychosis associated with polyneuritis, psychosis polyneuritica;

Korsakoff’s syndrome is a condition that mainly affects chronic alcoholics; It is due to the direct effects of alcohol or to the severe nutritional deficiencies that are associated with chronic alcoholism, and has been seen in association with vitamin B deficiency; The syndrome also occurs in other severe brain disturbances, ( paralysis, dementia, brain damage, infections and poisonings); In chronic alcoholism the condition usually occurs following delirium tremens; The syndrome is characterized by a severe memory defect, especially for recent event, for which the patient compensates by confabulation - the reciting of imaginary experiences; Psychologists working with these patients often have great problems sorting out what is truth and what is lies of what patients say - this is story-telling on a high level; Other symptoms may include delirium, anxiety, fear, depression, confusion, delusions and insomnia; painful extremities, sometimes bilateral wrist drop, more frequent bilateral foot drop with pain or pressure over the long nerves; Confabulation, a requisite for the classic syndrome, is not always present in mild conditions; With or without polyneuropathy;

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External Links Related to Korsakoff's psychosis/Alcohol dementia
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)