Disease Information for Korsakoff's psychosis/Alcohol dementia

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Clinical Manifestations
Signs & Symptoms
Alcohol facies
Failure to Thrive
Malnourished/poor nutrition status/signs
Alcohol on breath/odor of alcohol
Agnosognosia (Insite/awareness failure)
Altered mental status Mental status change
Amnesia/event, retrograde/antegrade
Apathy/Indifference
Ataxia
Behavior problems
Blackouts/Event amnesia/temporary
Cognitive defect
Confabulation
Confusion/Disoriented
Coordination/signs
Executive function loss/apathy/inertia
Gait disturbance/abnormality
Hand tremors
Memory Loss in Elderly
Near recall/memory deficit/defect
Nystagmus
Paucity of ideas/conversation
Personality change
Rapidly progressive dementia
Short term memory loss
Slurred speech
Slurred speech/Chronic
Stupor/poor reponse to stimulus
Sudden unconsciousness
Tremor
Tremor in Elderly
Tremor,fine
Behavior/life plans erratic
Destructive Behavior
Poverty of thought
Scattered thought process
Failure to Thrive/Adult
Disease Progression
Course/Acute
Course/Chronic disorder
Course/Prognosis bad/usually
Course/Relapsing
Demographics & Risk Factors
Established Disease Population
Patient/Alcoholism/chronic alcoholic
Patient/Excess alcohol habit
Population Group
Aged Adult
Man
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Male
Population/Man patient
Population/Middle-aged adult
Laboratory Tests
Abnormal Lab Findings - Decreased
RBC Transketolase activity (LAB)
Thiamine/Vitamin B1 (Lab)
URINE Thiamine
Abnormal Lab Findings - Increased
CDT [Carbohydrate-Deficience Transferrin test]/Abnormal
Ethanol blood level/toxin (Lab)
Pyruvate, plasma (Lab)
Diagnostic Test Results
Pathology
PATH/Brain Mammillary bodies defect/lesion
PATH/Brain Medial thalamus lesion
PATH/Brain/Glial proliferation/ganglion cell lysis
CT Scan
MRI/Head Mammillary Body lesions
MRI/Head/Medial Thalamus Lesion
Associated Diseases & Rule outs
Rule Outs
Creutzfeld-Jacob disease
Hepatic encephalopathy
Associated Disease & Complications
Alcohol dementia
Amnesia
CNS disease/involvement
Dementia
Hallucinations
Hypothalamic lesion
Korsakoff Psychosis/Alcohol Dementia
Neurobehavior Problems
Organic brain syndrome
Psychosis
Secondary Psychosis/Symptomatic
Sedation/torpor induced
Demyelinating Disease
Disease Synergy - Causes
Risk factor/Alcoholism
Synergy/Malnutrition
Disease Mechanism & Classification
Class
CLASS/Limbic System Lesion/Defect
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Mammillary bodies/lesion
Pathophysiology/Thiamine/pyrophosphate neurol metab
Process
PROCESS/Poison/specific (category)
PROCESS/Psychoses disorder (ex)
Synonyms
Synonym
ALCOHOL AMNESTIC DIS, Alcohol Amnestic Disorder, Alcohol amnestic disorder (disorder), Alcohol Amnestic Disorders, alcohol amnestic syndrome, Alcohol amnestic syndrome (disorder), Alcohol Amnestic Syndromes, ALCOHOL IND AMNESTIC PSYCHOSIS, ALCOHOL IND AMNESTIC SYNDROME, ALCOHOL IND DYSMNESIC PSYCHOSIS, ALCOHOL IND DYSMNESIC SYNDROME, ALCOHOL IND KORSAKOFF SYNDROME, ALCOHOL IND PERSISTING AMNESTIC DIS, Alcohol Induced Amnestic Psychoses, Alcohol Induced Amnestic Psychosis, Alcohol Induced Amnestic Syndrome, Alcohol Induced Amnestic Syndromes, Alcohol Induced Dysmnesic Psychoses, Alcohol Induced Dysmnesic Psychosis, Alcohol Induced Dysmnesic Syndrome, Alcohol Induced Dysmnesic Syndromes, Alcohol Induced Korsakoff Syndrome, Alcohol Induced Korsakoff Syndromes, Alcohol Induced Persisting Amnestic Disorder, Alcoholic amnestic syndrome, Alcoholic Korsakoff Syndrome, Alcoholic Korsakoff Syndromes, Alcoholic Korsakoff's Psychosis, alcoholic Korsakoff's syndrome, alcoholic Korsakov's psychosis, alcoholism Korsakov, Amnesic synd due to alcohol, Amnesic syndrome due alcohol, Amnesic syndrome due to alcohol, Amnestic Disorder Alcohol, Amnestic Disorders Alcohol, Amnestic Psychoses Alcohol Induced, AMNESTIC PSYCHOSIS ALCOHOL IND, Amnestic Psychosis Alcohol Induced, Amnestic Syndrome Alcohol, Amnestic Syndrome Alcohol Induced, Amnestic Syndromes Alcohol, Amnestic Syndromes Alcohol Induced, Dysmnesic Psychoses Alcohol Induced, Dysmnesic Psychosis Alcohol Induced, Dysmnesic Syndrome Alcohol Induced, Dysmnesic Syndromes Alcohol Induced, Korsakoff Syndrome Alcohol Induced, Korsakoff Syndrome Alcoholic, Korsakoff Syndromes Alcohol Induced, Korsakoff Syndromes Alcoholic, Korsakoffs alcoholic psychosis, Korsakoff's psychosis (alcoholic), Korsakoffs psychosis alcoholic, Korsakoff's psychosis alcoholic, Korsakov alcoholic psychosis, Korsakov alcoholism, Korsakov syndrome alcoholic, Korsakov's alcohol induced, Korsakov's psychosis alcohol induced, Korsakov's psychosis alcoholic, Mental and behav dis due to use alcohol amnesic syndrome, Mental and behavioral disorders due to use of alcohol amnesic syndrome, Mental and behavioral disorders due to use of alcohol amnesic syndrome (disorder), Mental and behavioural disorders due to use of alcohol amnesic syndrome, Psychoses Alcohol Induced Amnestic, Psychoses Alcohol Induced Dysmnesic, Psychosis Alcohol Induced Amnestic, Psychosis Alcohol Induced Dysmnesic, psychosis alcoholic Korsakov, psychosis alcoholic polyneuritic, psychosis Korsakov alcohol, Syndrome Alcohol Amnestic, Syndrome Alcohol Induced Amnestic, Syndrome Alcohol Induced Dysmnesic, Syndrome Alcohol Induced Korsakoff, Syndrome Alcoholic Korsakoff, syndrome amnestic alcohol, syndrome amnestic alcohol induced, Syndromes Alcohol Amnestic, Syndromes Alcohol Induced Amnestic, Syndromes Alcohol Induced Dysmnesic, Syndromes Alcohol Induced Korsakoff, Syndromes Alcoholic Korsakoff, Synonym/Alcohol Encephalopathy, Synonym/Alcoholic Polyneuritic Psychosis, Synonym/Wernicke-Korsakoff syndrome
Treatment
Drug Therapy - Indication
RX/Thiamine
Other Treatments
TX/Discontinue Toxin/Abuse
Definition

Korsakoff"s psychosis and syndrome; Korsakoff"s disease;

Korsakoff’s psychosis; Korsakoff’s symptom complex;

Meynert’s amentia; Amnestic confabulatory syndrome, amnestic syndrome, cerebropathia psychica toxemica, polyneuritic psychosis, psychosis associated with polyneuritis, psychosis polyneuritica;

Korsakoff’s syndrome is a condition that mainly affects chronic alcoholics; It is due to the direct effects of alcohol or to the severe nutritional deficiencies that are associated with chronic alcoholism, and has been seen in association with vitamin B deficiency; The syndrome also occurs in other severe brain disturbances, ( paralysis, dementia, brain damage, infections and poisonings); In chronic alcoholism the condition usually occurs following delirium tremens; The syndrome is characterized by a severe memory defect, especially for recent event, for which the patient compensates by confabulation - the reciting of imaginary experiences; Psychologists working with these patients often have great problems sorting out what is truth and what is lies of what patients say - this is story-telling on a high level; Other symptoms may include delirium, anxiety, fear, depression, confusion, delusions and insomnia; painful extremities, sometimes bilateral wrist drop, more frequent bilateral foot drop with pain or pressure over the long nerves; Confabulation, a requisite for the classic syndrome, is not always present in mild conditions; With or without polyneuropathy;

---------------------------[whonamedit.com 2005]---------

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Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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