Disease Information for Kleine-Levin syndrome

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Clinical Manifestations
Signs & Symptoms
Adolescent
Anorexia Decreased appetite
Appetite increased
Binge eating/purging behavior pattern
Excessive appetite/child
Hyperphagia
Polyphagia
Weight gain in Children
Apathy/Indifference
Behavior problems
Confusion on wakening/difficulty waking
Confusion/Disoriented
Daytime Sleepiness
Delirium
Drowsiness/somnolence
Irritability/short tempered
Lethargy/torpor
Sleep attacks/extreme daytime drowsiness
Destructive Behavior
Inappropriate sexuality
Episodic symptoms/events
Hypersomnia/Increased need for sleep
Weight gain
Typical Clinical Presentation
Presentation/Periodic somnolence/morbid hunger
Disease Progression
Course/3 to 5 Years
Course/Chronic disorder
Course/Chronic only
Course/One to two years
Course/Periodic Episodic
Course/Relapsing
Course/Self limited usually
Prognosis/Full recovery usual
Prognosis/Slow steady recovery
Demographics & Risk Factors
Past History
Past history/Encephalitis
Past history/Head injury
Established Disease Population
Patient/Bulemia/Eating disorder/Purging
Population Group
Child
Man
Population/Pediatrics population
Sex & Age Groups
Population/Adolescent
Population/Adult ('twenties')
Population/Boy patient
Population/Children/all
Population/Male
Population/Man patient
Population/Old child
Diagnostic Test Results
Electrodiagnosis
EEG/Abnormality
Associated Diseases & Rule outs
Rule Outs
Bulimia/Eating Disorder
Hypothalamic lesion
Kluver Bucy Bitemporal syndrome
Narcolepsy
Associated Disease & Complications
Amnesia
Eating disorder
Hallucinations
Hypothalamic dysfunction
Kleine-Levin syndrome
Nymphomania/hypersexuality female
Obesity
Obesity in Children
Obesity, massive
Satyriasis/hypersexuality male
Sedation/torpor induced
Disease Synergy - Causes
Synergy/General stress
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Endocrine gland (category)
CLASS/Hypothalamus/neurohypophysis involvement (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Sporadic/hereditary/process
Pathophysiology/Appestat/hypothalamic center stim
Pathophysiology/CNS depression
Pathophysiology/Dysomnia/hypersomnias (ex)
Pathophysiology/Maternal Chromosome mutation
Process
PROCESS/Autoimmune disorder (ex)
PROCESS/Autosomal dominant hereditary disease (ex).
PROCESS/Eponymic (category)
PROCESS/Genetic disorder/Spontaneous mutations/sporadic
PROCESS/Hereditofamilial (category)
PROCESS/INCIDENCE/Esoteric disease (example)
PROCESS/Metabolic/storage disorder (category)
PROCESS/Reference organ/system (category)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Synonyms
Synonym
Hypersomnia bulimia syndrome, Hypersomnia Periodic, Kleine Levin, Kleine Levin Critchley Syndrome, KLEINE LEVIN HIBERNATION SYNDROME, Kleine Levin Syndrome, Kleine Levin syndrome (disorder), Periodic Hypersomnia, Periodic Hypersomnias, syndrome hypersomnia bulimia, Syndrome Kleine Levin, Syndrome Kleine Levin Critchley, Synonym/Familial hibernation syndrome, Synonym/Hypersomnia bulimia syndrome, Synonym/Hypothalamic Hypersomnolence Syndrome, Synonym/Kleine-Levin Hibernating disorder, Synonym/Periodic somnolence, morbid hunger syndrome
Treatment
Drug Therapy - Indication
RX/Flumazenil (Mazicon)
Other Treatments
TX/Expectant/supportive treatment.
TX/Treatment often ineffective
Definition

A condition characterized by recurrent hypersomnia and hyperphagia and marked by such symptoms as mental confusion, excessive sleep requirements, restlessness, and hallucinations; Kleine Levin Syndrome; Familial Hibernation Syndrome ; Kleine-Levin Hibernation; Syndrome; Periodic Somnolence and Morbid Hunger; Kleine-Levin syndrome is a rare disorder characterized by the need for excessive amounts of sleep (hypersomnolence), (i.e., up to 20 hours a day); excessive food intake (compulsive hyperphagia); and an abnormally uninhibited sexual drive. The disorder primarily affects adolescent males. When awake, affected individuals may exhibit irritability, lack of energy (lethargy), and/or lack of emotions (apathy); They may also appear confused (disoriented) and experience hallucinations; Symptoms of Kleine-Levin Syndrome are cyclical; An affected individual may go for weeks or months without experiencing symptoms; When present, symptoms may persist for days to weeks; In some cases, the symptoms associated with Kleine-Levin syndrome eventually disappear with advancing age; However, episodes may recur later during life;

The exact cause of Kleine-Levin syndrome is not known. However, researchers believe that in some cases, the disorder may be inherited as an autosomal dominant genetic trait; It is thought that symptoms of Kleine-Levin syndrome may be related to malfunction of the portion of the brain that helps to regulate functions such as sleep, appetite, and body temperature (hypothalamus); (NORD rare disease org 2005) ---------------------------------------------

Kleine-Levin syndrome

Also known as:

Critchley"s syndrome

Kleine-Levin-Critchley syndrome

Synonyms:

Hypersomnia periodica, hibernation syndrome, hypersomnia-bulmia syndrome, hypersomnia-megaphagia syndrome, periodic hypersomnia-megaphagia syndrome, periodic somnolence, periodic somnolence and morbid hunger syndrome.

Associated persons:

MacDonald Critchley

Willi Kleine

Max Levin

Description:

A strange condition of unknown aetiology which almost exclusively affects young males aged 15-25 years. Characterized by periods lasting from days to weeks of attacks of somnolence accompanied by excessive food intake, and various mental symptoms. Common mental symptoms are confusion, irritability, restlessness, euphoria, hallucinations, delusions, and schizophreniform states. Attacks may occur every 3 to 6 months and last from 2 to 3 days. Between attacks the patients recover completely and the sleep periods usually disappear in adult age. This syndrome may easily be confused for other neurological, metabolical or psychiatric disease

[whonamedit.com 2005]

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External Links Related to Kleine-Levin syndrome
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Wikipedia
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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