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- Disease Information
- Disease Comparison
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Disease Processes ▼
- Auto Immune
- Vascular-Arteriosclerosis
- Biochemical
- Congenital-developmental
- Deficiency
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Major Organs-Systems ▼
- Systemic
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Disease Information for Job syndrome (Hyper IgE syndrome)
- Clinical Manifestations
- Signs & Symptoms
- Carbuncle/recurrent/present/sign
- Cold abscess/skin
- Furuncles present
- Painful subcutaneous nodules
- Reddish nodule/skin
- Tender nodules
- Hyperextensible digits
- Hyperextensible joints Laxity Instability
- Chronically ill patient/signs
- Clinical Presentation & Variations
- Presentation/Recurrent Infections
- Presentation/Lymphopenia Candidal diarrhea
- Disease Progression
- Course/Chronic disorder
- Course/Chronic only
- Course/Recurrent illness pattern
- Demographics & Risk Factors
- Established Disease Population
- Patient/Red hair
- Population Group
- Child
- Infant
- Population/Pediatrics population
- Family History
- Family history/Immune defects
- Sex & Age Groups
- Population/Boy patient
- Population/Child
- Population/Child-Infant Only
- Population/Children/all
- Population/Female
- Population/Girl patient
- Population/Infant
- Population/Infant female
- Population/Infant male
- Population/Male
- Laboratory Tests
- Microbiology & Serology Findings
- Microlab/Sputum/Eosinophiles on smear
- Abnormal Lab Findings (Non Measured)
- Chronic lymphopenia
- Abnormal Lab Findings - Decreased
- Lymphocytes (Lab)
- Abnormal Lab Findings - Increased
- Anti-staphylococcal IGE antibodies (Lab)
- Eosinophiles (LAB)
- IGE/Immunoglobulin E (Lab)
- Lymphocytes (Lab)
- Diagnostic Test Results
- Other Tests & Procedures
- Skin test anergy
- Associated Diseases & Rule outs
- Rule Outs
- Acne Fulminans
- Eczema/Dermatitis, atopic
- Associated Disease & Complications
- Anergic status
- Bronchitis, acute
- Candida albicans infection
- Carbuncle
- Cellular immunity defect/deficiency
- Cutaneous abscess/subcutaneous
- Eczema/Dermatitis, atopic
- Eosinophilia Hypereosinophilia
- Furunculosis
- Immunodeficiency
- Infections
- Job syndrome
- Lymphocytopenia
- Lymphocytosis
- Metastatic staphylococcus abscess syndrome
- Muscle abscess
- Otitis externa/acute
- Pneumonia, staphylococcus
- Sinusitis
- Staphylococcus aureus infection
- Staphylococcus sepsis
- Multiple Abscesses
- Disease Mechanism & Classification
- Class
- CLASS/Humoral Immune System Disorder (ex)
- CLASS/Pediatric disorders (ex)
- CLASS/Dermatologic/Subcutaneous (category)
- CLASS/Spleen/thymus/RES/immune system (category)
- Pathophysiology
- Pathophysiology/Abscess tendency
- Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
- Pathophysiology/Necrosis and abscess formation
- Pathophysiology/Chemotaxis failure/phagocytes/effect
- Pathophysiology/Decreased T Cells
- Pathophysiology/Defective cellular immunity
- Pathophysiology/Immune physiology/defective
- Pathophysiology/Immune/cellular system disorder (ex)
- Pathophysiology/Impaired neutrophile chemotaxis/dermis
- Pathophysiology/Poor anamnestic response/vaccines
- Process
- PROCESS/Allergy/collagen/autoimmune (category)
- PROCESS/Congenital/developmental (category)
- PROCESS/Eponymic (category)
- PROCESS/Hereditary/Genetic predisposition (ex)
- PROCESS/Hereditofamilial (category)
- PROCESS/Immunodeficiency disorder/Primary
- Synonyms
- Synonym
- HIE, Hyper IgE, Synonym/Atopic dermatitis/Neutrophile chemotaxis def, Synonym/Buckley's syndrome, Synonym/Hyper IGE/Recurrent infection syndrome, Synonym/Hyper-IGE syndrome, Synonym/Hyperimmunoglobulin E syndrome, Synonym/Job-Buckley syndrome, Synonym/Neutrophile chemotaxis failure/atopic derm.
- Treatment
- Drug Therapy - Indication
- RX/Antibiotic
- RX/Anti-staph/synthetic penicillin
- RX/Prophylactic measures/medication
- Surgical Procedures or Treatments
- SX/Surgery Incision/Drainage
- Definition
-
Job Syndrome; HIE Syndrome; Hyper-IgE Syndrome; Hyperimmunoglobulin E Syndrome; Hyperimmunoglobulin E-Recurrent Infection Syndrome; Hyperimmunoglobulinemia E-Staphylococcal; Job-Buckley Syndrome; Job Syndrome is an immunodeficiency syndrome characterized by recurrent bacterial (staphylococcal) infections, particularly of the skin, and markedly elevated IgE [Immunoglobulin E] levels; some autosomal dominant inheritance; Staphylococcal furuncles may involve the skin, lungs, joints and other sites; Some patients have coarse features; some are fair and redheaded; Decreased bone density and frequent fractures are common; Some dysfunctional neutrophils; Signs of allergy such as eczema, asthma and/or runny noses often; Treatment consists of intermittent or continuous antibiotics; Sexes are about equal frequency--------(NORD 2005)------------------------
Features include: coarse facies; lung infections;
skin infections; cold abscesses, which may affect bone and skin with staph as well as candida--------[gpnotebook website 2005]----------------
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- External Links Related to Job syndrome (Hyper IgE syndrome)
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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