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Disease Information for Isoniazid hepatitis

Clinical Manifestations
Signs & Symptoms: Yellow skin discoloration
: Anorexia Decreased appetite; Nausea; Right Upper Quadrant Pain/Tenderness; Upper Abdominal Pain; Vomiting
: Choluria/Biliuria in Elderly; Fever with Jaundice; Jaundice, recurrent; Jaundice/Yellow skin and eyes; Tender liver/liver pain; Yellow eyeballs/Scleral icterus
: Weak/Weak as a kitten (symptom)
: Altered mental status Mental status change; Fatigability; Sudden unconsciousness
: Dark urine
: Chronic Fatigue; Constitutional symptoms; Enervated/extreme acute fatigue; Fatigue; Fatigue Tiredness Exhaustion; Previous DX RX/doctor contact; Weakness; Weakness non-neuromuscular/systemic; Weight Loss
Disease Progression: Course/Acute; Course/Chronic disorder
Demographics & Risk Factors
Established Disease Population: Patient/Alcoholism/chronic alcoholic; Patient/Oral contraceptive/treatment
: Patient/Tuberculosis, chronic
Sex & Age Groups: Population/Adult/all; Population/Sixties-adult
Laboratory Tests
Abnormal Lab Findings (Non Measured): Fasting hypoglycemia (Lab); Hepatic Enzymes Abnormal (Lab); Liver Functions Abnormal (Lab); SGOT(AST)/SGPT(ALT) Less than 1.0 (Lab); Transaminase elevation (Lab)
Abnormal Lab Findings - Decreased: Folic acid/Folate (Lab); Glucose, blood (Lab); Neutrophiles (Lab); pH, arterial blood (Lab); Pyridoxine/Vitamin B6 (Lab)
Abnormal Lab Findings - Increased: ALT (SGPT) (Alanine transferase) (Lab); Ammonia blood (Lab); Aspartamine aminotransferase (SGOT, AST) (Lab); AST (SGOT) (aspartamine transferase) (Lab); Bilirubin, serum (Lab); Indirect bilirubin (Lab); Isocitric dehydrogenase (Lab); Lactic acid/Lactate (Lab); Lactic Dehydrogenase (LDH LH) (Lab); Methemoglobin (Lab); Nucleotidase/5 (Lab); Potassium, serum (Lab); PT -Prothrombin time (Lab); PTT/Partial Thromboplastin Time/Activated PTT (Lab)
: URINE Urobilinogen
Diagnostic Test Results
Pathology: BX/Liver biopsy/Centrilobular necrosis/hepatic congestion; BX/Liver biopsy/Periportal necrosis
Isotope Scan: Isotope/RAI uptake/quantitative high thyroid (I 123)
Associated Diseases & Rule outs
Rule Outs: Autoimmune hepatitis; Fatty liver of pregnancy; Hepatitis Delta Viral; Hepatitis E virus; Hepatitis, type B viral; Hepatitis, viral
: Chronic Hepatitis
Associated Disease & Complications: Acidosis; Acute hepatic necrosis/yellow atrophy; Bilirubinemia; Chronic hepatitis/Active; Drug induced Hepatic toxicity; Fulminant hepatic failure; Hepatic failure; Hepatitis, secondary; Hyperammonemia; Hyperkalemia; Hypoglycemia; Lactic acidosis; Toxic hepatitis; Vitamin B6/Pyridoxine deficiency
: Chronic Hepatitis
Disease Synergy - Causes: Synergy/Chronic alcoholism
Disease Mechanism & Classification
Class: CLASS/Liver involvement/disorder (ex); CLASS/Liver/gallbladder/ducts (category)
Drugs: DRUG/Antibiotic/antibacterial drug (example); DRUG/Antibiotic/Antimicrobial drugs (category)
Pathophysiology: Pathophysiology/Glissons capsule stretch/acute pain
Process: PROCESS/Complicating disorder (ex); PROCESS/Complicating/Specific process disorder (ex); PROCESS/Medication/Drug (CONFIRM dose/before treatment); PROCESS/Poisoned organ/system (category)
Treatment
Drug Therapy - Contraindication: RX/Isoniazide (INH)
Drug Therapy - Indication: RX/Acetylcysteine (Mucomist/NAC) (oral); RX/N-Acetylcysteine (NAC) IV ?; RX/Pyridoxine (Vitamin B6)
Definition: Be the first to add a definition for Isoniazid hepatitis
External Links Related to Isoniazid hepatitis: Google; Wikipedia; Merck; Images; PubMed (National Library of Medicine); NGC (National Guideline Clearinghouse); Medscape (eMedicine); Harrison's Online (accessmedicine); NEJM (The New England Journal of Medicine)

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