Disease Information for Irinotecan (Camptosar) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Baldness/Alopecia
Hair loss
Non-scarring Alopecia/balding
Laboratory Tests
Abnormal Lab Findings - Increased
Platelet count (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Agranulocytosis
Bone marrow failure/exhaustion
Drug fever
Drug induced Baldness/Alopecia
Drug induced Diarrhea.
Drug induced Hair loss
Drug induced Myelosuppression.
Drug induced Neutropenia.
Drug induced Thrombocytopenia.
Granulocytopenia/Neutropenia
Myelosuppression
Thrombocytopenia
Thrombocytosis
Disease Mechanism & Classification
Drugs
DRUG/Anti-neoplastic medications (examples)
DRUG/Anti-tumor plant alkaloids (example)
DRUG/Camptothecan analog/Alkaloid anti-cancer agent
DRUG/Camptothecin derivative drug (example)
DRUG/Derived from Asian happy tree (Camptotheca Acuminata)
DRUG/Topoisomerase I inhibitor anti-cancer drug
DRUG/Topoisomerase inhibitor anti-cancer drug
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
Irinotecan (Camptosar) admin, Brand name/Camptosar (Irinotecan), Synonym/CPT-11/Camptothecan 11 anti-cancer drug
Treatment
Drug Therapy - Indication
RX/Chemo Saltz Regimen Protocol
RX/IFL Chemotherapy protocol
Drug Dosage
DRUG/Injectable preparation only
Definition

Cancer chemotherapy drug; parenteral preparation; diarrhea, fever, weight loss, granulocytopenia, anemia, rare hair loss

primarily for ca colon and rectum with mets, now trials for neo-adjuvant ca esophagus; camptosar/cpt-11/camptothecan-11 analogue and cousin to toptecan plant alkaloid of asian/chinese happy tree [camptothecaa acuminata]; this is a topoisomerase type I inhibitor stoichoimetric interference with DNA formation--------[podophyllotoxins are type II inhibitors along with amsacrine; etoposide and teniposide are podophyllin plant alkaloids] Irinotecan is active as most are in cell cycle specific phase

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External Links Related to Irinotecan (Camptosar) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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