Disease Information for Infiltrative cardiomyopathy

restrictive cardiomyopathy infiltrative; Cardiomyopathy, Restrictive (PTG); Fred F Ferri MD; Cardiomyopathies are a group of diseases primarily involving the myocardium and characterized by myocardial dysfunction that is not the result of hypertension, coronary atherosclerosis, valvular dysfunction, or pericardial abnormalities; Restrictive cardiomyopathies are characterized by decreased ventricular compliance, usually secondary to infiltration of the myocardium; This is a relatively less cardiomyopathy that is most frequently caused by amyloidosis, myocardial fibrosis (after open heart surgery), and radiation, also hemochromatosis, sarcoidosis, and endomyocardial eosinophilia; CLINICAL PRESENTATION :Edema, ascites, hepatomegaly, distended neck veins ,Fatigue, weakness (secondary to low output) Kussmaul’s sign: may be present

Regurgitant murmurs; Possible prominent apical impulse

Infiltrative and storage disorders (glycogen storage disease, amyloidosis, sarcoidosis, hemochromatosis)

Scleroderma; Radiation; Endocardial fibroelastosis; Endomyocardial fibrosis; Idiopathic; Toxic effects of anthracycline; Carcinoid heart disease, metastatic cancers

Diabetic cardiomyopathy; Eosinophilic cardiomyopathy (Löffler’s endocarditis; Moderate cardiomegaly on X-ray CHF (pulmonary vascular congestion, pleural effusion); ECG: Low voltage with ST-T wave changes; frequent arrhythmias, left axis deviation, and atrial fibrillation; Echocardiogram: increased wall thickness and thickened cardiac valves (especially in patients with amyloidosis);Cardiac catheterization to distinguish restrictive cardiomyopathy from constrictive pericarditis ;Constrictive pericarditis: usually involves both ventricles and produces a plateau of elevated filling pressures; Restrictive cardiomyopathy: impairs the left ventricle more than the right (PCWP > RAP, PASP >50 mm Hg) MRI may also be useful to distinguish restrictive cardiomyopathy from constrictive pericarditis (thickness of the pericardium >5 mm in the latter)

[merck medicus website ferri clinical advisor 2005]

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