Disease Information for Infiltrative cardiomyopathy

Clinical Manifestations
Signs & Symptoms
PMI Displaced Lateral
Abnormal Heart Sounds
Abnormal Heart Sounds/Child
Cardiac Symptoms/Signs
Gallop,Ventricular/S3 Sound
Irregular rhythm/heartbeat
Third Heart Sound/S3 prominent
Demographics & Risk Factors
Established Disease Population
Diagnostic Test Results
Other Tests & Procedures
Cardiac index reduced
BX/Endomyocardial Biopsy Abnormal
BX/Myocardial biopsy/abnormal
Isotope Scan
Isotope/Cardiac Tch99 Pyrophosphate scan Abnormal
MUGA Scan/Cardiac abnormal
MUGA scan/cardiac output decreased
EKG/Pseudoinfarction pattern/Q Waves/atypical (ECG)
EKG/AV Nodal Block/Complete
EKG/Interventricular block/non-specific (ECG)
EKG/Left bundle branch block,complete (ECG)
EKG/Changes/abnormalities (ECG)
Fluoroscopy/Heart decreased pulsation/force
Fluoroscopy/Ventricular pulse diminished force
Echo/Echocardiogram Abnormal
Echo/Hypokinesis Zones
Echo/Stiff ventricular wall motion
Echo/Trans-esophageal echocardiograph/abnormal (TEE)
Associated Diseases & Rule outs
Rule Outs
Amyloidisis, heart
Cardiomyopathy, congested
Myocarditis, acute
Tamponade, cardiac/pericardial
Associated Disease & Complications
AV node lesion/infiltrate
Heart block, complete
Infiltrative cardiomyopathy
Ischemia, cardiac
Left bundle branch block
Left Ventricular Failure
Disease Mechanism & Classification
CLASS/Cardiovascular (category)
CLASS/Heart disorder (ex)
CLASS/Myocardial involvement/disorder (ex)
Pathophysiology/Infiltrative process
Pathophysiology/Myocardial infiltrate/Infiltrative (ex)
Pathophysiology/Myocardial Ischemia Functional
PROCESS/Complicating disorder (ex)
PROCESS/Pathophysiology/organ-system (category)

restrictive cardiomyopathy infiltrative; Cardiomyopathy, Restrictive (PTG); Fred F Ferri MD; Cardiomyopathies are a group of diseases primarily involving the myocardium and characterized by myocardial dysfunction that is not the result of hypertension, coronary atherosclerosis, valvular dysfunction, or pericardial abnormalities; Restrictive cardiomyopathies are characterized by decreased ventricular compliance, usually secondary to infiltration of the myocardium; This is a relatively less cardiomyopathy that is most frequently caused by amyloidosis, myocardial fibrosis (after open heart surgery), and radiation, also hemochromatosis, sarcoidosis, and endomyocardial eosinophilia; CLINICAL PRESENTATION :Edema, ascites, hepatomegaly, distended neck veins ,Fatigue, weakness (secondary to low output) Kussmaul’s sign: may be present

Regurgitant murmurs; Possible prominent apical impulse

Infiltrative and storage disorders (glycogen storage disease, amyloidosis, sarcoidosis, hemochromatosis)

Scleroderma; Radiation; Endocardial fibroelastosis; Endomyocardial fibrosis; Idiopathic; Toxic effects of anthracycline; Carcinoid heart disease, metastatic cancers

Diabetic cardiomyopathy; Eosinophilic cardiomyopathy (Löffler’s endocarditis; Moderate cardiomegaly on X-ray CHF (pulmonary vascular congestion, pleural effusion); ECG: Low voltage with ST-T wave changes; frequent arrhythmias, left axis deviation, and atrial fibrillation; Echocardiogram: increased wall thickness and thickened cardiac valves (especially in patients with amyloidosis);Cardiac catheterization to distinguish restrictive cardiomyopathy from constrictive pericarditis ;Constrictive pericarditis: usually involves both ventricles and produces a plateau of elevated filling pressures; Restrictive cardiomyopathy: impairs the left ventricle more than the right (PCWP > RAP, PASP >50 mm Hg) MRI may also be useful to distinguish restrictive cardiomyopathy from constrictive pericarditis (thickness of the pericardium >5 mm in the latter)

[merck medicus website ferri clinical advisor 2005]


External Links Related to Infiltrative cardiomyopathy
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)