Disease Information for Indomethacin (Indocin) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Baldness/Alopecia
Hair loss
Non-scarring Alopecia/balding
Impotence, relative
Confusion/Disoriented
Delirium
Delirium/Agitated delirium
Headache
Morning headaches
Nightmares/excess dreaming (Paroniria)
Nocturnal Headache
Seizures
Manic behavior
Nocturnal awakenings Events Phenomenon
Laboratory Tests
Abnormal Lab Findings - Decreased
Tryptophan (Lab)
Diagnostic Test Results
Other Tests & Procedures
Lumbar puncture/Increased CSF pressure/LP test
CT Scan
CT Scan/Head Brain Swelling/Edema
MRI/Head Brain Swelling/Edema
Associated Diseases & Rule outs
Rule Outs
Anxiety disorder/panic attacks
Associated Disease & Complications
Anemia, aplastic
Cerebral edema
CNS side effects
Convulsions (grand mal)
Drug induced Baldness/Alopecia
Drug induced Dreaming/nightmares (Paroniria)
Drug induced GI Blood Loss
Drug induced Impotence.
Drug induced Nephritis/Nephropathy
Drug induced Neutropenia.
Eosinophilic rhinitis, nonallergic
Granulocytopenia/Neutropenia
Hypersensitivity angiitis
Impotence/Erectile dysfunction disorder
Intracranial hypertension, benign
Nephritis, interstitial
Nephritis, non-allergic interstitial
Nephritis, secondary
Peptic ulcer disease
Pseudotumor cerebri
Toxic amblyopia syndrome
Toxic nephritis/Chronic persistent
Toxic Nephritis/Nephropathy
Urticaria/Drug Allergy
Urticaria/hives
Upper GI Bleeding in Elderly
Disease Synergy - Causes
Synergy/Congestive heart failure
Disease Mechanism & Classification
Drugs
DRUG/Anti-gout medication
DRUG/Anti-migraine medication (example)
DRUG/Antiphlogistic/NSAIDS drug (category)
DRUG/Antiplatelet/effect medication (example)
DRUG/Antipyetic/fever medication (ex)
DRUG/Non-steroidal anti-inflammatory drug (example)
DRUG/NSAID Acetic Acid derivative (ex)
DRUG/Teratogenic potential/effect (D plus )
DRUG/Tocolytic drug/effect (slows labor)
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/CSF Pressure Increased
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1 (4 chlorobenzoyl) 5 methoxy 2 methyl 1 H indole 3 acetic acid, 1H Indole 3 acetic acid 1 (4 chlorobenzoyl) 5 methoxy 2 methyl, INDO, Indometacin, Indometacin product, INDOMETHACIN, Indomethacin (product), Indomethacin (substance), INDOMETHACIN PREPARATION, Indomethacin product, Indomethacin product (substance), Brand name/Indocid (Indomethacin), Brand name/Indocin (Indomethacin), Brand name/Indotec (Indomethacin)
Treatment
Drug Therapy - Contraindication
RX/Warfarin (Coumadin)
Drug Dosage
DRUG/Dose 25 mgm (Unit/Pill/Capsule size)
DRUG/Dose 50 mgm (Unit/Pill/Capsule size)
DRUG/Dose Extended time release/XT/SA (example)
DRUG/Dose liquid/syrup/suspension form
DRUG/Dose p.c. (after meals/with meals)
DRUG/Dose Rectal enema/suppository available
DRUG/Dose TID Medication
DRUG/Generic available
DRUG/Oral medication (ex)
Definition

NSAID medication;Non-Steroidal Anti-Inflammatory drug;More COX1 than COX2 activity;Oral drug;Good CNS penetration;Used for more indications than others but more complications

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External Links Related to Indomethacin (Indocin) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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