Disease Information for Inappropriate ADH secretion

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Clinical Manifestations
Signs & Symptoms
Intracutaneous edema signs
Anorexia Decreased appetite
Nausea
Vomiting
Weight gain in Elderly
Cramping in Extremities
Altered mental status Mental status change
Confusion/Disoriented
Headache
Hyporeflexia/DTRs decreased
Irritability/short tempered
Lethargy/torpor
Neurologic manifestations/signs
Seizures
Sudden unconsciousness
Unconscious/Narcosis status
Weak reflexes
Weight gain
Clinical Presentation & Variations
Presentation/Confusion Elderly Postop Low Sodium
Demographics & Risk Factors
Established Disease Population
Patient/Surgical procedures recent
Patient/Hypothyroidism (myxedema)
Occupational Factors
Setting/Hospital setting
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Sixties-adult
Laboratory Tests
Abnormal Lab Findings - Decreased
Albumin, serum (Lab)
BUN/Blood urea nitrogen (Lab)
BUN/Creatinine ratio (Lab)
Calcium, serum (Lab)
Chloride serum (Lab)
Gamma globulin (Lab)
Globulin, serum (Lab)
Magnesium (Lab)
Osmolality, serum (Lab)
Potassium, serum (Lab)
Sodium, serum (Lab)
Uric acid, serum (Lab)
Abnormal Lab Findings - Increased
ADH/Antidiuretic Hormone/Vasopressin/Oxytocin level (Lab)
URINE Osmololality
URINE Sodium
URINE Specific gravity
Diagnostic Test Results
Other Tests & Procedures
TEST/Plasma Volume measurement/increased
Associated Diseases & Rule outs
Rule Outs
Cerebral salt-wasting syndrome
Hypogammaglobulinemia
Hypothalamic dysfunction
Associated Disease & Complications
Coma/Unconscious
Convulsions (grand mal)
Hallucinations
Hypoalbuminemia Hypoproteinemia
Hypocalcemia
Hypokalemia
Hypomagnesemia
Hyponatremia
Hypo-Osmolar State
Hypouricemia
Inappropriate ADH secretion syndrome
Magnesium deficiency
SIADH, idiopathic
Water retention
Disease Synergy - Causes
Synergy/Post Operative-Recent Surgery
Disease Mechanism & Classification
Class
CLASS/Endocrine gland (category)
CLASS/Hypothalamus/neurohypophysis involvement (ex)
Pathophysiology
Pathophysiology/High extracellular fluid volume
Pathophysiology/Volume redistribution
Pathophysiology/Paraneoplastic Endocrine Syndrome exists
Process
PROCESS/Endocrine/humoral disorders (category)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Synonyms
Synonym
ADH INAPPROPRIATE, ADH inappropriate secretion, ADH Syndrome Inappropriate, ANTIDIURETIC HORMONE INAPPROPRIATE SECRET, Antidiuretic Hormone Inappropriate Secretion, antidiuretic hormone inappropriate secretion (SIADH), ANTIDIURETIC HORMONE INAPPROPRIATE SECRETION SYNDROME (SIADH), ANTIDIURETIC HORMONE INAPPROPRIATE SECRETION SYNDROME SIADH, antidiuretic hormone syndrome (SIADH), hormone secretion antidiuretic inadequate (syndrome), hormone secretion antidiuretic inappropriate (syndrome), inadequate secretion antidiuretic hormone (syndrome), Inapprop ADH secretion syndrome, Inappropriate ADH, inappropriate ADH secretion, Inappropriate ADH syndrome, Inappropriate anti diuretic hormone syndrome, Inappropriate antidiuretic hormone secretion, Inappropriate Antidiuretic Hormone Secretion Syndrome, INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE, inappropriate secretion of antidiuretic hormone syndrome, INAPPROPRIATE VASOPRESSIN SECRET SYNDROME, Inappropriate vasopressin secretion, Inappropriate Vasopressin Secretion Syndrome, Schwartz Bartter Syndrome, Schwarz Bartter syndrome, secretion hormone antidiuretic inappropriate (syndrome), SIAD Syn inappr antidiuresis, SIAD Syndrome of inappropriate antidiuresis, SIADH, SIADH Synd inappr secret ADH, SIADH Syndrome of inappropriate secretion of ADH, SIADH Syndrome of inappropriate secretion of antidiuretic hormone, SIADH (syndrome of inappropriate secretion of antidiuretic hormone), Syndrome inappr secretion ADH, Syndrome inapprop antidiuresis, Syndrome inappropriate ADH, SYNDROME INAPPROPRIATE ADH SIADH SECRET, SYNDROME INAPPROPRIATE ANTI DIURETIC HORMONE, syndrome inappropriate secretion of antidiuretic hormone, SYNDROME OF INAPP ADH SECRETION, Syndrome of Inappropriate ADH (SIADH) Secretion, Syndrome of inappropriate ADH production, Syndrome of inappropriate antidiuresis, SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE, Syndrome of Inappropriate Antidiuretic Hormone Secretion, Syndrome of inappropriate secretion of ADH, Syndrome of inappropriate secretion of antidiuretic hormone, Syndrome of inappropriate vasopressin secretion, Syndrome of inappropriate vasopressin secretion (disorder), Syndrome Schwartz Bartter, Synonym/Cerebral hyponatremia syndrome, Synonym/Cerebral salt-wasting syndrome, Synonym/Schwartz-Bartter syndrome, Synonym/SIADHS
Treatment
Drug Therapy - Indication
RX/Demeclocycline (Declomycin)
RX/Tolvaptan (Samsca)
Other Treatments
TX/Fluid restriction
Definition

Hyponatremia and renal salt loss attributed to overexpansion of body fluids resulting from sustained release of VASOPRESSINS (i.e., antiduretic hormone) despite the absence of appropriate stimuli. Associated conditions include medication effect; MENINGITIS; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; CEREBROVASCULAR DISORDERS; HYDROCEPHALUS; PNEUMONIA; ASTHMA; THYROID DISEASES; and other conditions. This condition may also be idiopathic or result from ectopic (extra-pituitary) production of ADH. (From Joynt, Clinical Neurology, 1992, Ch36, pp59-62)

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NEJM (The New England Journal of Medicine)
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