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Disease Information for Imipramine (Tofranil) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Galactorrhea/Male

Lactorrhea in a male

Lactorrhea/Galactorrhea/Prolonged lactation

Tachycardia/Fast heart rate

Decreased sweating/Absent sweating

Impotence, relative

Retrograde ejaculation

Delirium/Agitated delirium

Disease Progression

Galactorrhea

Laboratory Tests

Abnormal Lab Findings - Increased

URINE 5-Hyroxyindole acetic acid

Diagnostic Test Results

EKG (ECG)

EKG/Widened QRS pattern (ECG)

EKG/AV Nodal Block/Complete

EKG/Changes/abnormalities (ECG)

Associated Diseases & Rule outs

Associated Disease & Complications

Anhydrosis/Absent sweating/diffuse

Anticholinergic/belladonna group toxidrome

Bradyarrhythmias

Cardiac arrhythmias

Cardiac conduction defects

Drug induced Arrhythmias

Drug induced Impotence.

Drug induced Movement disorder

Heart block, complete

Impotence/Erectile dysfunction disorder

Porphyria, attack, acute intermittant

Torsades de pointes/ventricular tachycardia

Tricyclic antidepressants/toxicity

Disease Mechanism & Classification

Drugs

DRUG/Anticholinergics effect/toxicity

DRUG/Antidepressant medication (examples)

DRUG/Anti-Narcolepsy medication (example)

DRUG/Dangerous for kids (10Kg)/Very

DRUG/Psychoactive/sedative drug (category)

DRUG/Safe in pregnancy patient (B)

DRUG/Tricyclic antidepressants (examples)

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Toxin

TOXIN/Causes Hyperthermia/Fever

Synonyms

Synonym

5H Dibenz(b f)azepine 5 propanamine 10 11 dihydro N N dimethyl, Imidobenzyle, Imipramine, Imipramine (product), Imipramine (substance), IMIPRAMINE PREPARATION, Imizin, Norchlorimipramine, Brand name/Impril (Imipramine), Brand name/Presamine (Imipramine), Brand name/Tofranil (Imipramine)

Treatment

Drug Dosage

DRUG/Dose 10 mgm (Unit/Pill/Capsule size)

DRUG/Dose 100 mgm (Unit/Pill/Capsule size)

DRUG/Dose 125 mgms (Unit/Pill/Capsule size)

DRUG/Dose 150 mgms (Unit/Pill/Capsule size)

DRUG/Dose 25 mgm (Unit/Pill/Capsule size)

DRUG/Dose 50 mgm (Unit/Pill/Capsule size)

DRUG/Dose 75 Mgm (Unit/Pill/Capsule size)

DRUG/Dose Hour of sleep/HS medication

DRUG/Dose once daily (RX)

DRUG/Generic available

DRUG/Intolerance in elderly/caution

DRUG/Oral medication (ex)

Definition

An anti-depressant drug; tricyclic antidepressant (TCA); oral preparation;all TCA medications have anti-cholinergic effects

(Edit)

External Links Related to Imipramine (Tofranil) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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