Disease Information for Ifosfamide (Ifex) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Baldness/Alopecia
Hair loss
Non-scarring Alopecia/balding
Altered taste/Taste perception
Laboratory Tests
Abnormal Lab Findings - Increased
Platelet count (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Acute Tubulointerstitial Nephropathy
Agranulocytosis
Bone marrow failure/exhaustion
Chemical cystitis
Cytoxan/Drug induced Cystitis
Drug induced Baldness/Alopecia
Drug induced Myelosuppression.
Drug induced Neutropenia.
Drug induced Renal failure,
Fetal anomaly
Granulocytopenia/Neutropenia
Hemorrhagic cystitis
Myelosuppression
Nephritis tubulointerstitial
Renal tubular acidosis, distal
Renal tubule acidosis, acquired
Thrombocytopenia
Thrombocytosis
Disease Mechanism & Classification
Drugs
DRUG/Alkylating agents (example)
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/Nitrogen mustard alkylating agent
DRUG/Teratogenic potential/effect (D plus )
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
2 oxo N 3 bis (2 chloroethyl) tetrahydro 2H 1 3 2 oxazaphosphorin 2 amine, 2H 1 3 2 Oxazaphosphorin 2 amine N 3 bis(2 chloroethyl)tetrahydro 2 oxide, 3 (2 chloroethyl) 2 ((2 chloroethyl)amino)tetrahydro 2H 1 3 2 oxazaphosphorin 2 oxide, IFF, IFO, ifosfamide, Ifosfamide (product), Ifosfamide (substance), IFOSFAMIDE PREPARATION, IFX, Iphosphamid, Iphosphamide, IPP, Iso Endoxan, Isoendoxan, Isofosfamide, isophosphamide, N 3 bis(2 chloroethyl)tetrahydro 2H 1 3 2 oxazaphosphorin 2 amine 2 oxide, Naxamide, Brand name/Ifex (Ifosfamide), Brand name/IFX (Ifosfamide)
Treatment
Drug Dosage
DRUG/Dose Unit dose Vial preparation
Definition

Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often.

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External Links Related to Ifosfamide (Ifex) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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