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Disease Information for Ifosfamide (Ifex) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Baldness/Alopecia

Hair loss

Non-scarring Alopecia/balding

Altered taste/Taste perception

Laboratory Tests

Abnormal Lab Findings - Increased

Platelet count (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Acute Tubulointerstitial Nephropathy

Agranulocytosis

Bone marrow failure/exhaustion

Chemical cystitis

Cytoxan/Drug induced Cystitis

Drug induced Baldness/Alopecia

Drug induced Myelosuppression.

Drug induced Neutropenia.

Drug induced Renal failure,

Fetal anomaly

Granulocytopenia/Neutropenia

Hemorrhagic cystitis

Myelosuppression

Nephritis tubulointerstitial

Renal tubular acidosis, distal

Renal tubule acidosis, acquired

Thrombocytopenia

Thrombocytosis

Disease Mechanism & Classification

Drugs

DRUG/Alkylating agents (example)

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Nitrogen mustard alkylating agent

DRUG/Teratogenic potential/effect (D plus )

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

2 oxo N 3 bis (2 chloroethyl) tetrahydro 2H 1 3 2 oxazaphosphorin 2 amine, 2H 1 3 2 Oxazaphosphorin 2 amine N 3 bis(2 chloroethyl)tetrahydro 2 oxide, 3 (2 chloroethyl) 2 ((2 chloroethyl)amino)tetrahydro 2H 1 3 2 oxazaphosphorin 2 oxide, IFF, IFO, ifosfamide, Ifosfamide (product), Ifosfamide (substance), IFOSFAMIDE PREPARATION, IFX, Iphosphamid, Iphosphamide, IPP, Iso Endoxan, Isoendoxan, Isofosfamide, isophosphamide, N 3 bis(2 chloroethyl)tetrahydro 2H 1 3 2 oxazaphosphorin 2 amine 2 oxide, Naxamide, Brand name/Ifex (Ifosfamide), Brand name/IFX (Ifosfamide)

Treatment

Drug Dosage

DRUG/Dose Unit dose Vial preparation

Definition

Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often.

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External Links Related to Ifosfamide (Ifex) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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