Disease Information for Hypereosinophilic syndrome

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Clinical Manifestations
Signs & Symptoms
Chest Pain
Red/erythema skin discoloration
Erythroderma
Fever and Rash
Hyperhidrosis/Chronic sweating excess
Night sweats
Pruritis Itching
Rash
Sweating Excess Perspiration
Symmetrical rash
Abdominal Pain
Abdominal Pain Crampy
Anorexia Decreased appetite
Palpable Liver/Hepatomegaly
Dysesthesias
Chest pain/non-cardiac
Cough
Cough Chronic
Dyspnea
Arthritis with Fever
Splenomegaly
Fever
Fever Febrile Possible
Fever of unknown origin/chronic fever
Flu-Like Syndrome
High body temperature
Malaise
Weight Loss
Disease Progression
Course/Chronic disorder
Course/Subacute
Onset/insidious
Demographics & Risk Factors
Sex & Age Groups
Population/Male
Laboratory Tests
Microbiology & Serology Findings
Stool Microscopic polys present
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Eosinophilic leukemoid reaction (Lab)
Extreme eosinophilia (Lab)
Abnormal Lab Findings - Decreased
Hematocrit (Lab)
Hemoglobin (Lab)
RBC/Red Blood Count (Lab)
Abnormal Lab Findings - Increased
Eosinophiles (LAB)
WBC
IGE/Immunoglobulin E (Lab)
WBC/White Blood Cell Count/Leukocytes (Lab)
Diagnostic Test Results
Pathology
BX/Myocardial biopsy/cellular infiltrate
PATH/Myocardial eosinophilic infiltrate
BX/Skin biopsy/eosinophile infiltrate
Bone Marrow/Eosinophilia/adult forms
Bone Marrow/Ratio myeloproliferative increase
PATH/Eosinophilic infiltrate/tissue
EKG (ECG)
EKG/Non-specific ST-T Wave changes (ECG)
X-RAY
Xray/Cardiomegaly/Chest
Xray/Chest abnormal
Xray/Chest film/extrapulmonary abnormal
Xray/Chest/Lung fields/Abnormal
Xray/Infiltrate, pulmonary/Chest
Xray/Pulmonary fibrosis/Chest
Xray/Pulmonary infiltrate eosinophilia (PIE/Loeffler's syndrome)
Associated Diseases & Rule outs
Rule Outs
Behcet's syndrome
Churg Strauss pulmonary vasculitis
Eosinophilia, tropical
Eosinophilia-polymyalgia syndrome
Eosinophilic pneumonia/prolonged
Leukemia, eosinophilic
Loefflers/Eosinophilic pneumonia, acute
Polyarteritis nodosa
Associated Disease & Complications
Acquired valvular heart disease
Anemia
AV node lesion/infiltrate
Bradyarrhythmias
Cardiomyopathy, end stage
Congestive heart failure
Death/Unanticipated
Eosinophilia Hypereosinophilia
Eosinophilic pneumonia/prolonged
Heart block, complete
Leukemoid reaction
Leukocytosis
Loeffler's endocarditis
Mononeuritis, multiplex
Multi-radicular Polyneuropathy syndrome
Mural thrombosis, heart
Myocardial conduction abnormalities
Peripheral neuropathy
Polyneuritis
Pulmonary eosinophilia syndrome
Pulmonary fibrosis
Polyneuropathy
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
Pathophysiology
Pathophysiology/Myocardial infiltrate/Infiltrative (ex)
Pathophysiology/Exertional O2 desaturation
Pathophysiology/FIP1L1-PDGFRc1 fusion mutation
Pathophysiology/Tissue infiltrate
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Neoplastic (category)
PROCESS/Paraneoplastic disorder (ex)
Treatment
Drug Therapy - Indication
RX/Corticosteroid (Cortisone)
RX/Hydroxyurea (Hydrea)
RX/Imatinib (Gleevec/Glivec)
RX/Vincristine (Oncovin)
Definition

A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of eosinophils in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs. It is often referred to as idiopathic.

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External Links Related to Hypereosinophilic syndrome
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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