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Disease Information for Hydralazine (Apresoline) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Low Blood Pressure

Palpitations/Skipped beats

Pulse pressure/wide

Tachycardia/Fast heart rate

Impotence, relative

Lymphadenopathy

Lymphadenopathy Systemic

Paresthesias

Laboratory Tests

Abnormal Lab Findings - Increased

Anti-cardiolipin (Lab)

Anti-Histone antibody (Lab)

ANA, homogenous/serum (Lab)

ANA/Antinuclear antibody/Fluorescent ANA (Lab)

Anti-Nuclear Antibody (ANA)

Direct Coombs test (Lab)

LE Prep/Lupus erythematosis cell prep (Lab)

P-ANCA antibodies (Lab)

Diagnostic Test Results

Pathology

BX/Liver biopsy/Granulomas in liver

Associated Diseases & Rule outs

Associated Disease & Complications

Drug induced Impotence.

Drug induced Lupus Erythematosis/syndrome

Drug induced Peripheral neuropathy.

Eosinophilic pneumonia/prolonged

Erythema multiforme

Granulomatous liver/hepatitis syndrome

Hypotension

Impotence/Erectile dysfunction disorder

Lupus erythematosis, systemic

Pericarditis, acute

Pleurisy

Priapism/persistent erection

Pulmonary eosinophilia syndrome

Disease Mechanism & Classification

Drugs

DRUG/Alpha adrenergic blocker/peripheral effect

DRUG/Antihypertensive medication (examples)

DRUG/Anti-hypertensive/injectable medication (example)

DRUG/Direct arteriolar vasodilator (example)

DRUG/Important Acute care drugs (example)

DRUG/Injectable antihypertensive med (example)

DRUG/Older medication/little used

DRUG/Prazocin-like antihypertensive (example)

DRUG/Safe in pregnancy patient (B)

DRUG/Specialized usage (example)

DRUG-Liver metabolism/bile excretion

Pathophysiology

Pathophysiology/Granulomatous liver disease

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

1(2H) Phthalazinone Hydrazone, Apressin, Apressinum, Hydralazine, Hydralazine (product), Hydralazine (substance), HYDRALAZINE PREPARATION, Hydrallazin, Hydrazinophthalazine, Brand name/Apresazide (Hydralazine-HCZ) Comb, Brand name/Apresoline (Hydralazine-Reserpine-HCZ), Brand name/Bidil ( Isosorbide/Hydralazine) Comb. ), Brand name/Ser-Ap-Es (comb.)

Treatment

Drug Dosage

DRUG/.1990 or before

DRUG/Dose 10 mgm (Unit/Pill/Capsule size)

DRUG/Dose 25 mgm (Unit/Pill/Capsule size)

DRUG/Dose TID Medication

DRUG/Generic available

DRUG/Injectable medication (parenteral)

DRUG/Intramuscular injection RX

DRUG/Oral medication (ex)

Definition

Alpha adrenergic blocker drug effects peripheral alpha receptors. Vasodilator and Anti-hypertensive drug. Safe in pregnancy but high frequency of drug induced DLE. Oral and

parenteral drug.

(Edit)

External Links Related to Hydralazine (Apresoline) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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