Disease Information for Hydralazine (Apresoline) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Low Blood Pressure
Palpitations/Skipped beats
Pulse pressure/wide
Tachycardia/Fast heart rate
Impotence, relative
Lymphadenopathy
Lymphadenopathy Systemic
Paresthesias
Laboratory Tests
Abnormal Lab Findings - Increased
Anti-cardiolipin (Lab)
Anti-Histone antibody (Lab)
ANA, homogenous/serum (Lab)
ANA/Antinuclear antibody/Fluorescent ANA (Lab)
Anti-Nuclear Antibody (ANA)
Direct Coombs test (Lab)
LE Prep/Lupus erythematosis cell prep (Lab)
P-ANCA antibodies (Lab)
Diagnostic Test Results
Pathology
BX/Liver biopsy/Granulomas in liver
Associated Diseases & Rule outs
Associated Disease & Complications
Drug induced Impotence.
Drug induced Lupus Erythematosis/syndrome
Drug induced Peripheral neuropathy.
Eosinophilic pneumonia/prolonged
Erythema multiforme
Granulomatous liver/hepatitis syndrome
Hypotension
Impotence/Erectile dysfunction disorder
Lupus erythematosis, systemic
Pericarditis, acute
Pleurisy
Priapism/persistent erection
Pulmonary eosinophilia syndrome
Disease Mechanism & Classification
Drugs
DRUG/Alpha adrenergic blocker/peripheral effect
DRUG/Antihypertensive medication (examples)
DRUG/Anti-hypertensive/injectable medication (example)
DRUG/Direct arteriolar vasodilator (example)
DRUG/Important Acute care drugs (example)
DRUG/Injectable antihypertensive med (example)
DRUG/Older medication/little used
DRUG/Prazocin-like antihypertensive (example)
DRUG/Safe in pregnancy patient (B)
DRUG/Specialized usage (example)
DRUG-Liver metabolism/bile excretion
Pathophysiology
Pathophysiology/Granulomatous liver disease
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1(2H) Phthalazinone Hydrazone, Apressin, Apressinum, Hydralazine, Hydralazine (product), Hydralazine (substance), HYDRALAZINE PREPARATION, Hydrallazin, Hydrazinophthalazine, Brand name/Apresazide (Hydralazine-HCZ) Comb, Brand name/Apresoline (Hydralazine-Reserpine-HCZ), Brand name/Bidil ( Isosorbide/Hydralazine) Comb. ), Brand name/Ser-Ap-Es (comb.)
Treatment
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 10 mgm (Unit/Pill/Capsule size)
DRUG/Dose 25 mgm (Unit/Pill/Capsule size)
DRUG/Dose TID Medication
DRUG/Generic available
DRUG/Injectable medication (parenteral)
DRUG/Intramuscular injection RX
DRUG/Oral medication (ex)
Definition

Alpha adrenergic blocker drug effects peripheral alpha receptors. Vasodilator and Anti-hypertensive drug. Safe in pregnancy but high frequency of drug induced DLE. Oral and

parenteral drug.

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External Links Related to Hydralazine (Apresoline) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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