Disease Information for Hungry bone syndrome/recovery deficit

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Clinical Manifestations
Signs & Symptoms
Acute bilateral Hand muscle spasms
Cramping in Extremities
Bone Pains
Sternal swelling
Sternal tenderness
Tender Bones (Long Bones)
Stridor (Inspiratory noise)
Stridor infant Child
Laboratory Tests
Abnormal Lab Findings - Decreased
Calcium, serum (Lab)
Magnesium (Lab)
Phosphate Serum (Lab)
Abnormal Lab Findings - Increased
Osteocalcin (Lab)
Phospholipids, serum (Lab)
URINE N-Telopeptide Crosslinks levels
Associated Diseases & Rule outs
Associated Disease & Complications
Hungry bone syndrome/deficit recovery
Hypocalcemia
Hypomagnesemia
Hypophosphatemia
Iatrogenic disorder/complication/effects
Magnesium deficiency
Periostitis
Tetany
Disease Mechanism & Classification
Class
CLASS/Endocrine gland (category)
CLASS/Bone disorder (ex)
CLASS/Skeletal (category)
Process
PROCESS/Deficiency (category)
PROCESS/Iatrogenic (category)
PROCESS/Pathophysiologic disorder (category)
Treatment
Drug Therapy - Indication
RX/Phosphate/Potassium
Definition

Parathyroidism (primary and secondary)and Thyrotoxicosis leadi to overactive osteoblastic activity coupled with a reduced osteoclastic activity and followed by post-surgery rebound results in a net calcium from circulation.

This is the proposed mechanism of Hungry Bone Syndrome leading to hypocalcaemia.

"Hungry Bone Syndrome""Hungry Bone Syndrome" Classically after removal of hyperparathyroid active adenoma in primary hyperparathyoidism.

Recalcification that occurs in bone postoperatively, after thyrotoxicosis or hyperparathyroidism is referred to as "hungry bone syndrome", due to a rapid increase in bone remodeling. If the stimulus is removed (thyroid hormone or parathyroid hormone), there is a dramatic increase in bone formation. Hypocalcemia can occur if the rate of skeletal mineralization exceeds the rate of osteoclast-mediated bone resorption. This syndrome can be associated with severe and diffuse bone pain.

Another cause of hypocalcemia is osteoblast metastases in a patient with prostate or breast cancer. The setting of acute leukemia or osteosarcomatosis can also result in hypocalcemia. In patients with vitamin D deficiency and symptoms of osteomalacia, institution of vitamin D therapy can result in hypocalcemia. All of these disease states result in hypocalcemia due to mineralization of large amounts of unmineralized osteoid.

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External Links Related to Hungry bone syndrome/recovery deficit
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Wikipedia
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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