Disease Information for Human Herpes Virus 7/Roseola Infantum agent

Clinical Manifestations
Signs & Symptoms
Red/erythema skin discoloration
Cheek/facial skin distribution
Erythematous generalized rash
Fever and Rash
Macular rash
Non-pruritic rash
Papular Rash
Rash transient/evanescent
Rash, macular/maculopapular or morbilliform
Diarrhea in Children
Febrile seizure/children
Apparently well Silent disorder possible
Constitutional symptoms
Fever clears then rash
Fever Febrile Possible
Fever in kids
Fever, high
Flu-Like Syndrome
High body temperature
Toxic and Febrile Septic
Typical Clinical Presentation
Viremia Sepsis with low WBC
Clinical Presentation & Variations
Presentation/Rash appears Fever ends Child Exanthem
Disease Progression
Course/Acute only
Demographics & Risk Factors
Population Group
Population/Pediatrics population
Sex & Age Groups
Population/Child-Infant Only
Population/Preschool child/boy
Laboratory Tests
Microbiology & Serology Findings
Human herpes virus/HHV-6 antibodies (labs)
Human herpes virus/HHV-7 antibodies positive
Roseola/Measles antibody titer (labs)
Serum specific antibodies increased
Microlab/HHV-6 virus (human herpes 6)
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Right Shift (Viral) Differential Smear (Lab)
Normal Urinalysis
Abnormal Lab Findings - Decreased
Neutrophiles (Lab)
WBC/White Blood Cell Count/Leukocytes (Lab)
Abnormal Lab Findings - Increased
Atypical lymphocytes (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Acute Neutropenia Caused by Infection
Febrile convulsion
Toddlers diarrhea
Viral exanthematous diseases
Disease Mechanism & Classification
Specific Agent
AGENT/Exanthematous infection (ex)
AGENT/Highly Contagious/infectious
AGENT/Virus (category)
CLASS/Pediatric disorders (ex)
PROCESS/Infection/agent specific (category)
B Lymphotropic Virus Human, B Lymphotropic Viruses Human, Exanthem subitum virus, HBLV, herpes simplex virus type 6, herpesvirus 6 HHV 6, Herpesvirus 6 Human, HERPESVIRUS HUMAN 06, Herpesvirus type 6, HHV 6, HHV6, HHV6 Human herpes virus 6, Human B Lymphotropic Virus, Human B Lymphotropic Viruses, Human herpes virus 6, HUMAN HERPESVIRUS 06, human herpesvirus 6, Human herpesvirus 6 (organism), human herpesvirus 6 HHV 6, Human herpesvirus type 6, human herpesvirus type 6 HHV 6, HUMAN LYMPHOTROPIC VIRUS AB, Roseola infantum virus, Roseola virus, Virus HHV6, Synonym/HHV7, Synonym/Red measles (roseola infantum/hhv-6)

HHV-7 was discovered in 1990 and is member of the betaherpesvirus family, closely related to both HHV-6 and cytomegalovirus (CMV);Of the 3 viruses, HHV-7 is the least pathogenic; Like its cousin HHV-6, an HHV-7 primary infection causes roseola infantum in infants and young children, which is an undifferentiated, febrile illness that typically lasts for 6 days; Symptoms include a rash on the neck and trunk, as well as mild upper respiratory infection and cervical lymphadenopathy; Complications include febrile seizures, meningitis and encephalitis, as well as neurological complications (in individuals with active CNS infection); Otitis and gastroenteritis have also been reported in these patients;HHV-7 is typically acquired prior to age 5, and is thought to affect over 95% of the population; After primary infection, HHV-7 establishes latency in the host, which predisposes individuals to reactivation during periods of time when their immune systems are not functioning properly; Because the rate of prevalence of HHV-7 is so high in the general population, it is thought that viral reactivation or enhancement of replication takes place after a liver transplant, due to the immunocompromised nature of the human host in the period of time immediately after transplant; The incidence of HHV-7 infections post liver transplantation has been reported to be as high as 45%; Reactivation typically takes place within 2-8 weeks after the transplant; Post-transplant infections have also been documented in BMT patients;


External Links Related to Human Herpes Virus 7/Roseola Infantum agent
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)