Disease Information for Hepatotoxic drugs

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Clinical Manifestations
Signs & Symptoms
Yellow skin discoloration
Anorexia Decreased appetite
Anorexia in Elderly
Nausea
Vomiting
Acholic Stools
Choluria/Biluria/Bilirubin urine
Intermittant mild jaundice
Palpable Liver/Hepatomegaly
Tender liver/liver pain
Fatigability
Fatigue
Fatigue Tiredness Exhaustion
Malaise
Demographics & Risk Factors
Established Disease Population
Patient/On Medications long term/ usually
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Hepatic Enzymes Abnormal (Lab)
Liver Functions Abnormal (Lab)
Transaminase elevation (Lab)
URINE Color Brown
Abnormal Lab Findings - Increased
ALT (SGPT) (Alanine transferase) (Lab)
Aspartamine aminotransferase (SGOT, AST) (Lab)
AST (SGOT) (aspartamine transferase) (Lab)
Bilirubin, serum (Lab)
LDH isoenzyme 5 (Lab)
URINE Bilirubin
Diagnostic Test Results
Pathology
BX/Liver biopsy/Hepatocyte necrosis
Associated Diseases & Rule outs
Associated Disease & Complications
Bilirubinemia
Cholestasis/intrahepatic biliary obstruction
Cholestatic Jaundice Syndrome
Cirrhosis
Drug induced Cholestasis hepatitis
Obstructive jaundice syndrome
Toxic hepatitis
Disease Mechanism & Classification
Class
CLASS/Liver involvement/disorder (ex)
Pathophysiology
Pathophysiology/Liver cell necrosis
Process
PROCESS/Complicating disorder (ex)
PROCESS/Drug induced disorder (ex)
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Treatment
Drug Therapy - Indication
RX/N-Acetylcysteine (NAC) IV ?
Definition
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External Links Related to Hepatotoxic drugs
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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