Disease Information for Hepatic vein occlusion/thrombus

Clinical Manifestations
Signs & Symptoms
Edema Children
Thorax/vein distension
Prominent venous plexus/cutaneous
Yellow skin discoloration
Abdominal Distension
Abdominal distension/protrusion/sign
Abdominal Distention
Abdominal Pain
Abdominal Pain Crampy
Abdominal venous engorgement/collaterals
Caput medusa/abdomen
Right Upper Quadrant Pain/Tenderness
Signs of ascites
Upper Abdominal Pain
Chest/truncal venous distension
Jaundice/Yellow skin and eyes
Liver smooth enlarged
Liver/Hepatic symptoms and signs
Palpable Liver/Hepatomegaly
Tender liver/liver pain
Yellow eyeballs/Scleral icterus
Longstanding splenomegaly
Tender spleen
Demographics & Risk Factors
Established Disease Population
Patient/Polycythemia vera
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Fasting hypoglycemia (Lab)
Hepatic Enzymes Abnormal (Lab)
Liver Functions Abnormal (Lab)
SAAG Serum Ascites-albumin gradient/high (Lab)
Transaminase elevation (Lab)
Abnormal Lab Findings - Decreased
Albumin, serum (Lab)
BUN/Blood urea nitrogen (Lab)
Cholesterol (Lab)
Glucose, blood (Lab)
Abnormal Lab Findings - Increased
Alkaline phosphatase, serum (Lab)
ALT (SGPT) (Alanine transferase) (Lab)
Aspartamine aminotransferase (SGOT, AST) (Lab)
AST (SGOT) (aspartamine transferase) (Lab)
Bilirubin, serum (Lab)
Diagnostic Test Results
Other Tests & Procedures
Gastroscopy/Esophageal varices
BX/Liver biopsy/Abnormal
BX/Liver biopsy/Central lobular necrosis
CT Scan
CT Scan/Liver Caudate Lobe Enlarged
CT Scan/Liver Portasystemic venous collaterals
Xray/Peritoneal fluid/child/ABD
Xray/Azygos vein enlarged/Chest
X-RAY With contrast
UGI/Esophageal varices
Ultrasound/Abdomen Abnormal
Ultrasound/Abdomen and pelvis abnormal
Ultrasound/Upper abdomen abnormal
Ultrasound/Liver Abnormal
Ultrasound/Spleen enlarged
Angios/Liver abnormality
Angios/liver hepatic vein occlusion
Associated Diseases & Rule outs
Rule Outs
Fatty liver of pregnancy
Associated Disease & Complications
Ascites in Children
Edema of newborn
Esophageal varices
Gastric varices
Hepatic encephalopathy
Hepatic necrosis, subacute
Hepatic vein thrombosis (Budd-Chiari)
Hepatitis, secondary
Hepatorenal syndrome
Hypoalbuminemia Hypoproteinemia
Massive pulmonary embolism
Peritoneal Effusion
Portal hypertension
Portal vein thrombosis
Protein losing enteropathy
Pulmonary embolism
Splenomegaly congestive, chronic
Veno-occlusive hepatic disease
Disease Mechanism & Classification
Specific Agent
Pathophysiology/Hepatic Congestion
CLASS/Cardiovascular (category)
CLASS/Vein disorder (ex).
CLASS/Liver/gallbladder/ducts (category)
CLASS/Portal vein/hepatic venous disorder (ex)
Pathophysiology/Ascites, exudative process/effect
Pathophysiology/Bleeding from Portal Veins
Pathophysiology/Glissons capsule stretch/acute pain
Pathophysiology/Post-sinusoidal Portal Hypertension
Pathophysiology/Venous stasis/liver blood flow
PROCESS/Arteriosclerosis/vascular/venous (category)
PROCESS/Structural/anatomic/foreign body (category)
PROCESS/Thrombosing process (ex)
PROCESS/Inflammatory/Vascular/venous/phlebitis (ex)
Hepatic vein occlusion, Synonym/Budd-Chiari syndrome/hepatic vein, Synonym/Budd's syndrome, Synonym/Chiari-Budd syndrome, Synonym/Chiari's disease, Synonym/Hepatic vein obstruction/thrombosis, Synonym/Hepatic veno-occlusive disease, Synonym/Rokitansky's disease
Drug Therapy - Indication
SX/Angioplasty/Balloon procedures/all types
SX/Portacaval shunting/TIPS
Surgical Procedures or Treatments

Hepatic vein thrombosis occurs in cancer patients, pregnancy, oral contraceptives, thrombophilia states including nocturnal hemoglobinuria; can be insidious portal hypertension, ascites,jaundice,cirrhosis; or acutely with epigastric pain,shock, (also portal vein thrombosis;may need liver transplant.------------------------------------------------Budd Chiari Syndrome

Budd"s Syndrome

Chiari"s Disease

Chiari-Budd Syndrome

Hepatic Veno-Occlusive Disease

Rokitansky"s Disease

Disorder Subdivisions

General Discussion

Budd-Chiari syndrome is a rare disorder characterized by narrowing and obstruction (occlusion) of the veins of the liver (hepatic veins). Symptoms associated with Budd Chiari syndrome include pain in the upper right part of the abdomen, an abnormally large liver (hepatomegaly), and/or accumulation of fluid in the space (peritoneal cavity) between the two layers of the membrane that lines the stomach (ascites). Additional findings that may be associated with the disorder include nausea, vomiting, and/or an abnormally large spleen (splenomegaly). The severity of the disorder varies from case to case, depending upon the site and number of affected veins. In some cases, if the major hepatic veins are involved, high blood pressure in the veins carrying blood from the gastrointestinal (GI) tract back to the heart through the liver (portal hypertension) may be present. In most cases, the exact cause of Budd-Chiari syndrome is unknown.[NORD 2005]---------------------.

Also known as:

Budd"s disease

Budd"s jaundice

Chiari’s disease

Chiari’s syndrome

Rokitansky’s disease

von Rokitansky disease


Acute parenchymatous jaundice, acute yellow atrophy of the liver, hepatic vein thrombosis, post-necrotic cirrhosis of the liver

Associated persons:

George Budd

Hans Chiari

Karl Freiherr von Rokitansky


A rare disorder marked by cirrhosis of the liver and ascites due to an obstruction of the hepatic vein by a blood clot or tumor. Characteristically the caudate lobe of the liver is spared due to direct venous channels from the inferior vena cava. Clinical symptoms include hepatomegaly, sudden abdominal epigastric pain with nausea and vomiting, and ascites. Associated disorders usually include jaundice, haematemesis, leg oedema, oesophageal varices, thrombophlebitis of the inferior vena cava, and portal hypertension. Occurs in an acuta and an intermittent form. More common in males.[whonamedit.com 2005]


External Links Related to Hepatic vein occlusion/thrombus
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)