Disease Information for Heparin induced thrombocytopenia synd

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Clinical Manifestations
Signs & Symptoms
Onset 5th to 10th Day RX
Acute Limb ischemia
Chest Pain
Heparin Injection Site Necrosis
High blood pressure/sign
Previous Clot Now enlarging
Tachycardia/Fast heart rate
Petechial hemorrhages/subcutaneous
Purpura
Rash
Arm pain at rest
Lower leg pain/unilateral
Dyspnea
Chills
Fever
Disease Progression
Course/Acute
Demographics & Risk Factors
Established Disease Population
Patient/On Medications long term/ usually
Patient/Post surgical status/postoperative
Sex & Age Groups
Population/Female
Laboratory Tests
Microbiology & Serology Findings
Serum specific antibodies increased
Abnormal Lab Findings (Non Measured)
Serotonin Release Assay abnormal
Abnormal Lab Findings - Decreased
Platelet count (Lab)
Abnormal Lab Findings - Increased
Anti-HIT (Heparin induced Thrombocytopenia) antibody
Heparin thrombocytopenia antibody test positive
Platelet Antibody Detection
Diagnostic Test Results
Ultrasound
Ultrasound/Extremities Abnormal
Associated Diseases & Rule outs
Rule Outs
Antiphospholipid Syndrome/APLS
Disseminated intravascular coagulation
Drug induced Thrombocytopenia.
Hemolytic-uremic syndrome
Purpura, idiopathic thrombocytopenic
Sepsis, overwhelming
Thrombocytopenic purpura, chronic
Thrombotic thrombocytopenic purpura
Warfarin induced/skin necrosis
Gangrene extremities
Associated Disease & Complications
Anaphylaxis, generalized
Arterial Occlusion
Bleeding diathesis/hemorrhagic diathesis
Bleeding Tendency
Brachial/axillary artery occlusion
Cerebral vascular accident
Drug induced Bleeding/hemorrhagic complication
Drug induced Thrombocytopenia.
Epistaxis/nosebleed
Heparin Induced Thrombocytopenia
Heparin Injection Anaphylaxis
Heparin toxicity
Hypercoagulability/Thrombophilia
Myocardial infarction, acute
Necrosis, tissue
Peripheral arterial embolism/extremity
Pulmonary embolism
Purpura fulminans
Sinus tachycardia
Skin necrosis/infarct
Thrombocytopenia
Thrombocytopenia in Elderly
Thrombocytopenia, autoimmune
Thromboembolic disease
Thrombophlebitis Arm/Deep Vein
Thrombophlebitis, deep vein
Thrombophlebitis, Superficial
Thrombosis, arterial
Venous Thrombosis
Digital gangrene
Gangrene extremities
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
Drugs
DRUG/Reaction to medication/drug induced (ex)
Pathophysiology
Pathophysiology/Arterial Occlusion
Pathophysiology/Antibodies Heparin-Platelet-factor 4 complexes
Pathophysiology/Intravasular coagulation process
Pathophysiology/Platelet factor 4 binds heparin/antigen function
Pathophysiology/Platelet Factor 4-Heparin autoantibodies
Pathophysiology/Spontaneous Coagulation
Process
PROCESS/Complicating disorder (ex)
PROCESS/Complicating/Specific process disorder (ex)
PROCESS/Drug induced disorder (ex)
PROCESS/Poisoned organ/system (category)
PROCESS/Thrombosing process (ex)
Synonyms
Synonym
Heparin induced thrombocytopen, HEPARIN INDUCED THROMBOCYTOPENIA, Heparin induced thrombocytopenia (disorder), Synonym/HIT
Treatment
Drug Therapy - Contraindication
RX/Heparin
RX/Warfarin (Coumadin)
Drug Therapy - Indication
PX/LMW Heparin Prophylaxis
RX/Argatroban (Thrombocytope)
RX/Danaparoid (Orgaran)
RX/Hirudin analog
RX/Lepirudin (Refluden)
RX/Vitamin K
Definition

Natural product anticoagulant drug; parenteral preparation; can cause thrombocytopenia/microthrombi syndrome

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External Links Related to Heparin induced thrombocytopenia synd
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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