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Disease Information for Hand-Schuller-Christian syndrome

Clinical Manifestations
Signs & Symptoms: Dandruff
: Delayed female adolescence
: Gingival swelling; Loose teeth/falling out; Precocious teeth eruption/child
: Lymphadenopathy Systemic
: Proptosis,bilateral; Proptosis,unilateral
Clinical Presentation & Variations: Presentation/Triad DI Exophthalmous Bone lesions
Disease Progression: Course/Chronic disorder; Course/Chronic only
Demographics & Risk Factors
Population Group: Child; Population/Pediatrics population
Sex & Age Groups: Population/Boy patient; Population/Child; Population/Child-Infant Only; Population/Children/all; Population/Preschool child
Laboratory Tests
Abnormal Lab Findings (Non Measured): Hyperprolactinemia
Abnormal Lab Findings - Increased: Prolactin (Lab)
Diagnostic Test Results
Pathology: BX/Lung biopsy/Granulomas in lung
: BX/Bone biopsy/abnormal
: PATH/Langerhans' histiocyte/Birbeck granules/electronmicr; PATH/Langerhans' histiocyte/CD1 cell surface; PATH/Langerhans' histiocyte/Immune S100 protein; PATH/Langerhans' histiocyte/Pale distinct/abundant cytoplasm; PATH/Langerhans' histiocytes present; PATH/Langerhans' histiocytes/Coffee bean nucleus
CT Scan: MRI/Orbits abnormality
X-RAY: Xray/Chest abnormal
: Xray/Auditory meatus widened or eroded/Skull
: Xray/Chest/Lung fields/Abnormal; Xray/Lung lesion/localized/Chest
: Xray/Bone abnormality; Xray/Bone lesion, solitary lytic; Xray/Bone lesions, multiple 'punched out'; Xray/Multiple lytic lesions of skull; Xray/Skull abnormality; Xray/Skull single lytic lesion
Associated Diseases & Rule outs
Rule Outs: Ewings sarcoma; Hypothalamic dysfunction; Osteogenic sarcoma; Osteomyelitis; Prolactinoma, pituitary
Associated Disease & Complications: Central diabetes insipidus; Diabetes insipidus; Exophthalmos; Gingival hyperplasia; Hand-Schuller-Christian disease; Hypothalamic lesion; Mastoiditis; Otitis externa, chronic; Otitis media; Panhypopituitarism
: Mass in Bone
Disease Mechanism & Classification
Class: CLASS/Langerhan Cell/Tissue Macrophages involvement/disorder (ex); CLASS/Pediatric disorders (ex)
: CLASS/Hypothalamus/neurohypophysis involvement (ex)
: CLASS/Gum/gingival involvement/disorder (ex)
Pathophysiology: Pathophysiology/Multisystem disease
: Pathophysiology/Langerhans/histiocyte cell disease/LCD (ex)
: Pathophysiology/Bone involvement/lesion
: Pathophysiology/Immunoregulatory defect/causal
Process: PROCESS/Eponymic (category); PROCESS/Inflammatory/Granulomatous disorder (category); PROCESS/Metabolic/storage disorder (category); PROCESS/Storage disorder (ex)
: PROCESS/Proliferative/infiltrative disorder (ex)
: PROCESS/Orbital inflammatory disease
Synonyms
Synonym: Chronic differentiated progressive histiocytosis, Chronic disseminated histiocytosis X, Chronic Histiocytosis X, Chronic idiopathic xanthomatosis, EOSINOPHILIC GRANULOMA MULTIFOCAL, Generalised histiocytosis of bones, Generalized histiocytosis of bones, Hand Schuller Christian disease, Hand Schueller Christian disease, Hand Schueller Christian Syndrome, Hand Schuller Christian, Hand Schüller Christian, Hand Schuller Christian diseas, Hand Schuller Christian disease, Hand Schüller Christian disease, Hand Schuller Christian disease (disorder), Hand Schüller Christian disease (disorder), Hand Schuller Christian disease (obs), Hand Schuller Christian syndr, Histiocytosis X (chronic), Histiocytosis X chronic, HISTIOCYTOSIS X II, Langerhans cell histiocytosis multifocal, Langerhans cell histiocytosis multifocal (morphologic abnormality), Langerhans cell histiocytosis poly ostotic, SCHUELLER CHRISTIAN DISEASE, Schuller Christian, Schüller Christian, Schuller Christian syndrome, Systemic reticuloendothelial granuloma, X histiocytosis chronic, Synonym/Christians disease, Synonym/Craniohypophyseal xanthoma syndrome, Synonym/Disseminated langerhans' histiocytosis, Synonym/Multifocal eosinophilic granuloma syndrome, Synonym/Schuller disease, Synonym/Xanthomatosis, chronic idiopathic
Definition: Be the first to add a definition for Hand-Schuller-Christian syndrome
External Links Related to Hand-Schuller-Christian syndrome: Google; Wikipedia; Merck; Images; PubMed (National Library of Medicine); NGC (National Guideline Clearinghouse); Medscape (eMedicine); Harrison's Online (accessmedicine); NEJM (The New England Journal of Medicine)

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