Disease Information for Gordons Arthrogryposis, Familal

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Clinical Manifestations
Signs & Symptoms
Arthritis Children
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
Definition

Gordon Syndrome; Arthrogryposis Multiplex Congenita, Distal, Type IIA; Camptodactyly-Cleft Palate-Clubfoot;

Distal Arthrogryposis, Type IIA; Gordon syndrome is an extremely rare disorder that belongs to a group of genetic disorders known as the distal arthrogryposes; These disorders typically involve stiffness and impaired mobility of certain joints of the lower arms and legs (distal extremities) including the knees, elbows, wrists, and/or ankles; These joints tend to be permanently fixed in a bent or flexed position (contractures); Gordon syndrome is characterized by the permanent fixation of several fingers in a flexed position (camptodactyly), abnormal bending inward of the foot (clubfoot or talipes), and, less frequently, incomplete closure of the roof of the mouth (cleft palate); In some cases, additional abnormalities may also be present; The range and severity of symptoms may vary from case to case; Gordon syndrome is inherited as an autosomal dominant trait-----------[NORD 2005]---------

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