Disease Information for Gilbert's syndrome

Clinical Manifestations
Signs & Symptoms
Yellow skin discoloration
Fasting intolerant
Intermittant mild jaundice
Jaundice/Yellow skin and eyes
Yellow eyeballs/Scleral icterus
Apparently well Silent disorder possible
Asymptomatic patient
Clinical Presentation & Variations
Presentation/Transient Jaundice Viremias Normal patient
Disease Progression
Course/Benign course/disorder
Course/Chronic disorder
Course/Chronic only
Course/Usually/No complications
Demographics & Risk Factors
Population Group
Population/Pediatrics population
Family History
Family history/Liver disease
Sex & Age Groups
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Indirect bilirubin inc/normal direct bil. (Lab)
Liver Functions Abnormal (Lab)
Abnormal Lab Findings - Increased
Bilirubin, serum (Lab)
Indirect bilirubin (Lab)
Postprandial normalization of bilirubin
Diagnostic Test Results
Other Tests & Procedures
TEST Iv nicotinic acid increases unconjugated bilirubin
BX/Liver biopsy/Lipofuschin stain deposits
BX/Liver biopsy/Normal
Isotope Scan
Isotope/Hepatic bilirubin clearance study/abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Gilberts syndrome
Neonatal hyperbilirubinemia
Disease Synergy - Causes
Synergy/Hemolytic anemia
Synergy/Inadequate diet
Synergy/Low fat
Synergy/Viral illness/acute
Disease Mechanism & Classification
Pathophysiology/Disordered bilirubin metabolism
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Defect glucuronyl transferase /UDP
Pathophysiology/Plasma bilirubin cell uptake failure
PROCESS/Autosomal recessive disorder (ex)
PROCESS/Enzyme defect/Metabolic disorder (ex)
PROCESS/Eponymic (category)
PROCESS/Hereditofamilial (category)
PROCESS/Metabolic/storage disorder (category)
PROCESS/Inherited bilirubin metabolism disorder (ex)
Benign unconjugated bilirubinaemia syndrome, Benign unconjugated bilirubinemia syndrome, bilirubinemia familial nonhemolytic, Cholaemia familiaris simplex, cholemia familial, Cholemia familiaris simplex, cholemia Gilbert, Chronic intermittent juvenile jaundice, Congenital familial cholaemia, Congenital familial cholemia, congenital nonhemolytic jaundice, Constitutional hepatic dysfunction, Constitutional hepatic dysfunction syndrome, Constitutional hyperbilirubinemia, Disease Gilbert, Disease Gilberts, Disease Gilbert's, familial cholemia, familial jaundice nonhemolytic, Familial non hemolytic jaundice, Familial nonhaemolytic bilirubinaemia, Familial nonhaemolytic jaundice, Familial nonhemolytic bilirubinemia, Familial nonhemolytic jaundice, Gilbert, Gilbert cholemia, GILBERT DIS, GILBERT DISEASE, GILBERT LEREBOULLET SYNDROME, GILBERT SYNDROME, GILBERTS DIS, Gilberts disease, GILBERT'S DISEASE, GILBERTS SYNDROME, Gilbert's syndrome, Gilbert's syndrome (disorder), Hereditary nonhaemolytic jaundice, hereditary nonhemolytic jaundice, HYPERBILIRUBINEMIA ARIAS TYPE, HYPERBILIRUBINEMIA CHRONIC UNCONJUGATED, Hyperbilirubinemia constitutional, HYPERBILIRUBINEMIA FAMILIAL UNCONJUGATED, HYPERBILIRUBINEMIA I, Hyperbilirubinemia unconjugated chronic non hemolytic, jaundice familial nonhemolytic, jaundice nonhemolitic congenital familial, Low grade chronic hyperbilirubinaemia syndrome, Low grade chronic hyperbilirubinemia syndrome, Meulengracht syndrome, nonhemolitic congenital familial jaundice, Synonym/Gilbert-Lereboullet syndrome, Synonym/Hyperbilirubinemia, familial unconjugated
Drug Therapy - Contraindication
RX/Niacin/Nicotinic acid
Drug Therapy - Indication

A benign hereditary disorder, transmitted as an autosomal dominant trait; It is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level; Unconjugated bilirubin increases with fasting, illness, and decreases to normal after eating; liver biopsy is normal but not needed; a test with iv nicotinic acid (niacin/vitamin b2) confirms diagnosis; excellent prognosis-------------------

Gilbert Syndrome; Constitutional Liver Dysfunction;

Familial Jaundice; Gilbert"s Disease;

Gilbert-Lereboullet Syndrome;Hyperbilirubinemia I;

Icterus Intermittens Juvenalis; Meulengracht"s Disease;

Unconjugated Benign Bilirubinemia;

One of a benign (harmless) group of metabolic abnormalities, Gilbert Syndrome is a hereditary disorder leading to a defect in the clearance (removal) of bile pigment (bilirubin) from the liver; This syndrome is common but innocuous and easily controllable-----[NORD 2005]-------


External Links Related to Gilbert's syndrome
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)