Disease Information for Frontotemporal dementia

Clinical Manifestations
Signs & Symptoms
Failure to Thrive
Hand muscle spasms/cramps
Interosseous muscle wasting/hand
Intrinsic hand muscle wasting/sign
Thenar muscle wasting
Alien limb syndrome
Apraxic gait ('slipping clutch'/hesitant)
Behavior problems
Frontal lobe signs
Lower motor neuron lesion/signs
Memory Loss in Elderly
Myoclonus/Myoclonic jerks on exam
Near recall/memory deficit/defect
Neurological symptoms/signs
Paucity of ideas/conversation
Personality change
Progressive neurological disorder/signs
Rapidly progressive dementia
Short term memory loss
Destructive Behavior
Poverty of thought
Urinary Incontinence in Elderly
Clinical Presentation & Variations
Presentation/Progressive Dementia
Disease Progression
Course/Circadian rhythm, same time event/flair
Demographics & Risk Factors
Population Group
Aged Adult
Family History
Family history/Dementia
Sex & Age Groups
Population/Adult Aged Only
Population/Elderly Aged
Population/Seventies Adult
Diagnostic Test Results
Other Tests & Procedures
TEST/Verbal fluency Mini Mental Abnormal
PATH/Hyperphosphorylated Tau microtubule deposits
Pathophysiology/Tauopathy (Tau positive deposits) CNS
CT Scan
MRI/Head Scan Abnormal
PET Scan/Head FDDNP abnormal
Associated Diseases & Rule outs
Rule Outs
Alcohol amnestic disorder
Amyotrophic lateral sclerosis
Creutzfeld-Jacob disease
Dementia, Lewy body type
Korsakoff Psychosis/Alcohol Dementia
Normal pressure hydrocephalus
Parkinsons disease
Associated Disease & Complications
Extrapyramidal disease/manifestation
Frontotemporal dementia
Neurobehavior Problems
Neurodevelopmental disorders
Secondary Psychosis/Symptomatic
Disease Mechanism & Classification
Pathophysiology/Gene locus 17q21.1
Pathophysiology/Gene locus Chromosome 17q
Pathophysiology/Tau Gene locus at 17/mutant gene
Pathophysiology/CNS degeneration
Pathophysiology/Neurologic degenerative disorder (ex)
PROCESS/Degenerative/necrosis disorder (category)
PROCESS/Developmental degenerative neurological disorder (ex)
Degeneration Frontotemporal Lobar, Degenerations Frontotemporal Lobar, Frontotemporal Lobar Degeneration, Frontotemporal Lobar Degenerations, FTLD, Lobar Degeneration Frontotemporal, Lobar Degenerations Frontotemporal, Synonym/FTD

Synonym FTD; frontotemporal dementia; faster variant of CNS degeneration syndrome; present with behavioral, personality, and cognitive changes; frontal lobe syndrome progressing to dementia over years; occasionally faster; bulbar involvement with ALS like features; FTD; FRONTOTEMPORAL LOBAR DEGENERATION; DEMENTIA, FRONTOTEMPORAL, WITH PARKINSONISM; FRONTOTEMPORAL DEMENTIA WITH PARKINSONISM; FRONTOTEMPORAL LOBE DEMENTIA; MULTIPLE SYSTEM TAUOPATHY WITH PRESENILE DEMENTIA; DISINHIBITION DEMENTIA-PARKINSONISM-AMYOTROPHY COMPLEX; WILHELMSEN-LYNCH DISEASE; FRONTOTEMPORAL DEMENTIA-AMYOTROPHIC LATERAL SCLEROSIS; Gene map locus 17q21-1, 14q24-3; some forms of frontotemporal dementia are caused by mutation in the gene encoding microtubule-associated protein tau (MAPT) on chromosome 17; other loci for frontotemporal dementia have been mapped to chromosome 3 and chromosome 9q; this is a familial adult-onset behavioral disturbance followed by frontal lobe dementia, parkinsonism, and amyotrophy in variable proportions; FTD is usually a sporadic mutation; Tauopathies variable group of neurodegenerative diseases with overlapping features characterized neuropathologically by abnormal tau protein filaments; Pathology: Neuropathologic Frontotemporal atrophy and neuronal loss superficial (layer 2) spongiform change, and neuronal loss with gliosis in the substantia nigra and amygdala;


External Links Related to Frontotemporal dementia
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)