Disease Information for Frontotemporal dementia

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Clinical Manifestations
Signs & Symptoms
Failure to Thrive
Hand muscle spasms/cramps
Interosseous muscle wasting/hand
Intrinsic hand muscle wasting/sign
Thenar muscle wasting
Alien limb syndrome
Apraxic gait ('slipping clutch'/hesitant)
Behavior problems
Frontal lobe signs
Inattention
Lower motor neuron lesion/signs
Memory Loss in Elderly
Myoclonus/Myoclonic jerks on exam
Near recall/memory deficit/defect
Neurological symptoms/signs
Paucity of ideas/conversation
Personality change
Progressive neurological disorder/signs
Rapidly progressive dementia
Short term memory loss
Destructive Behavior
Poverty of thought
Urinary Incontinence in Elderly
Clinical Presentation & Variations
Presentation/Progressive Dementia
Disease Progression
Course/Circadian rhythm, same time event/flair
Course/Progressive
Demographics & Risk Factors
Population Group
Aged Adult
Family History
Family history/Dementia
Sex & Age Groups
Population/Adult Aged Only
Population/Elderly Aged
Population/Seventies Adult
Diagnostic Test Results
Other Tests & Procedures
TEST/Verbal fluency Mini Mental Abnormal
Pathology
PATH/Hyperphosphorylated Tau microtubule deposits
Pathophysiology/Tauopathy (Tau positive deposits) CNS
CT Scan
MRI/Head Scan Abnormal
PET Scan/Head FDDNP abnormal
Associated Diseases & Rule outs
Rule Outs
Alcohol amnestic disorder
Amyotrophic lateral sclerosis
Creutzfeld-Jacob disease
Dementia, Lewy body type
Korsakoff Psychosis/Alcohol Dementia
Narcissism
Normal pressure hydrocephalus
Parkinsons disease
Associated Disease & Complications
Amnesia
Dementia
Extrapyramidal disease/manifestation
Frontotemporal dementia
Hallucinations
Neurobehavior Problems
Neurodevelopmental disorders
Psychosis
Secondary Psychosis/Symptomatic
Disease Mechanism & Classification
Pathophysiology
Pathophysiology/Gene locus 17q21.1
Pathophysiology/Gene locus Chromosome 17q
Pathophysiology/Tau Gene locus at 17/mutant gene
Pathophysiology/CNS degeneration
Pathophysiology/Neurologic degenerative disorder (ex)
Process
PROCESS/Degenerative/necrosis disorder (category)
PROCESS/Developmental degenerative neurological disorder (ex)
Synonyms
Synonym
Degeneration Frontotemporal Lobar, Degenerations Frontotemporal Lobar, Frontotemporal Lobar Degeneration, Frontotemporal Lobar Degenerations, FTLD, Lobar Degeneration Frontotemporal, Lobar Degenerations Frontotemporal, Synonym/FTD
Definition

Synonym FTD; frontotemporal dementia; faster variant of CNS degeneration syndrome; present with behavioral, personality, and cognitive changes; frontal lobe syndrome progressing to dementia over years; occasionally faster; bulbar involvement with ALS like features; FTD; FRONTOTEMPORAL LOBAR DEGENERATION; DEMENTIA, FRONTOTEMPORAL, WITH PARKINSONISM; FRONTOTEMPORAL DEMENTIA WITH PARKINSONISM; FRONTOTEMPORAL LOBE DEMENTIA; MULTIPLE SYSTEM TAUOPATHY WITH PRESENILE DEMENTIA; DISINHIBITION DEMENTIA-PARKINSONISM-AMYOTROPHY COMPLEX; WILHELMSEN-LYNCH DISEASE; FRONTOTEMPORAL DEMENTIA-AMYOTROPHIC LATERAL SCLEROSIS; Gene map locus 17q21-1, 14q24-3; some forms of frontotemporal dementia are caused by mutation in the gene encoding microtubule-associated protein tau (MAPT) on chromosome 17; other loci for frontotemporal dementia have been mapped to chromosome 3 and chromosome 9q; this is a familial adult-onset behavioral disturbance followed by frontal lobe dementia, parkinsonism, and amyotrophy in variable proportions; FTD is usually a sporadic mutation; Tauopathies variable group of neurodegenerative diseases with overlapping features characterized neuropathologically by abnormal tau protein filaments; Pathology: Neuropathologic Frontotemporal atrophy and neuronal loss superficial (layer 2) spongiform change, and neuronal loss with gliosis in the substantia nigra and amygdala;

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External Links Related to Frontotemporal dementia
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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