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Disease Information for Fluphenazine (Prolixin/Permitil) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Dizzy on Standing/Giddy Response

Orthostatic drop in blood pressure

Impotence, relative

Dry mouth/Mucous membranes

Motor restlessness

Akathisia

Athetosis

Choreoathetoid movement

Dystonia, acquired

Odd body posturing

Seizures

Stupor/poor reponse to stimulus

Tremor

Unable to sit still/restlessness

Blurred Cloudy Vision

Difficulty Focusing Eyes

Dimming vision/acute

Diplopia Double vision

Laboratory Tests

Abnormal Lab Findings - Increased

Neutrophiles (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Cardiac arrhythmias

Convulsions (grand mal)

Drug induced Acute dystonia reaction

Drug Induced Choreoathetosis

Drug induced Impotence.

Drug induced Inappropriate ADH syndrome/SIADHS

Drug induced Movement disorder

Drug induced Orthostatic hypotension

Impotence/Erectile dysfunction disorder

Neuroleptic malignant syndrome

Orthostatic hypotension syndrome

Orthostatic syncope Hypotension

Parkinsonism, secondary

Priapism/persistent erection

Sedation/torpor induced

Tardive dyskinesia syndrome

Urinary bladder retention

Disease Mechanism & Classification

Drugs

DRUG/Antipsychotic/neuroleptic drug (example)

DRUG/Anti-Schizophrenia medication (example)

DRUG/D2 Receptor dopamine antagonist (Ex)

DRUG/Phenothiazine class drug (example)

DRUG/Psychoactive/sedative drug (category)

DRUG/Lowers seizure threshold

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

1 Piperazineethanol 4 (3 (2 (trifluoromethyl) 10H phenothiazin 10 yl)propyl), 1 Piperazineethanol 4 (3 (2 (trifluoromethyl) 10H phenothiazin 10 yl)propyl) (9CI), Flufenazin, fluphenazine, Fluphenazine (product), Fluphenazine (substance), FLUPHENAZINE PREPARATION, Brand name/Modecate (Fluphenazine), Brand name/Moditen (Fluphenazine), Brand name/Permitil (Fluphenazine), Brand name/Prolixin (Fluphenazine)

Treatment

Drug Dosage

DRUG/.1990 or before

DRUG/Dose 1 mgm (Unit/Pill/Capsule size)

DRUG/Dose 2.5 mgm (Unit/Pill/Capsule size).

DRUG/Dose 5 mgm (Unit/Pill/Capsule size)

DRUG/Dose Depot injection option

DRUG/Dose liquid/syrup/suspension form

DRUG/Dose must be titrated to effect

DRUG/Dose Q6 hrs Medication

DRUG/Dose Q8 Hrs Medication

DRUG/Dose TID Medication

DRUG/Generic available

DRUG/Injectable medication (parenteral)

DRUG/Intramuscular injection RX

DRUG/Oral medication (ex)

Definition

Thorazine-like drug; class of neuroleptic drugs for anti-psychosis effect; oral and parenteral drug; causes sedation, tardive dyskinesia; basal ganglia effects; wide margin of safety

(Edit)

External Links Related to Fluphenazine (Prolixin/Permitil) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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