Disease Information for Fluphenazine (Prolixin/Permitil) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Impotence, relative
Dry mouth/Mucous membranes
Motor restlessness
Akathisia
Athetosis
Choreoathetoid movement
Dystonia, acquired
Odd body posturing
Seizures
Stupor/poor reponse to stimulus
Tremor
Unable to sit still/restlessness
Blurred Cloudy Vision
Difficulty Focusing Eyes
Dimming vision/acute
Diplopia Double vision
Laboratory Tests
Abnormal Lab Findings - Increased
Neutrophiles (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Cardiac arrhythmias
Convulsions (grand mal)
Drug induced Acute dystonia reaction
Drug Induced Choreoathetosis
Drug induced Impotence.
Drug induced Inappropriate ADH syndrome/SIADHS
Drug induced Movement disorder
Drug induced Orthostatic hypotension
Impotence/Erectile dysfunction disorder
Neuroleptic malignant syndrome
Orthostatic hypotension syndrome
Orthostatic syncope Hypotension
Parkinsonism, secondary
Priapism/persistent erection
Sedation/torpor induced
Tardive dyskinesia syndrome
Urinary bladder retention
Disease Mechanism & Classification
Drugs
DRUG/Antipsychotic/neuroleptic drug (example)
DRUG/Anti-Schizophrenia medication (example)
DRUG/D2 Receptor dopamine antagonist (Ex)
DRUG/Phenothiazine class drug (example)
DRUG/Psychoactive/sedative drug (category)
DRUG/Lowers seizure threshold
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1 Piperazineethanol 4 (3 (2 (trifluoromethyl) 10H phenothiazin 10 yl)propyl), 1 Piperazineethanol 4 (3 (2 (trifluoromethyl) 10H phenothiazin 10 yl)propyl) (9CI), Flufenazin, fluphenazine, Fluphenazine (product), Fluphenazine (substance), FLUPHENAZINE PREPARATION, Brand name/Modecate (Fluphenazine), Brand name/Moditen (Fluphenazine), Brand name/Permitil (Fluphenazine), Brand name/Prolixin (Fluphenazine)
Treatment
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 1 mgm (Unit/Pill/Capsule size)
DRUG/Dose 2.5 mgm (Unit/Pill/Capsule size).
DRUG/Dose 5 mgm (Unit/Pill/Capsule size)
DRUG/Dose Depot injection option
DRUG/Dose liquid/syrup/suspension form
DRUG/Dose must be titrated to effect
DRUG/Dose Q6 hrs Medication
DRUG/Dose Q8 Hrs Medication
DRUG/Dose TID Medication
DRUG/Generic available
DRUG/Injectable medication (parenteral)
DRUG/Intramuscular injection RX
DRUG/Oral medication (ex)
Definition

Thorazine-like drug; class of neuroleptic drugs for anti-psychosis effect; oral and parenteral drug; causes sedation, tardive dyskinesia; basal ganglia effects; wide margin of safety

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External Links Related to Fluphenazine (Prolixin/Permitil) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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