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Disease Information for Fluoxetine (Prozac) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Spontaneous ejaculation

Hypereactive/on exam

Agitation

Chronic/recurrent anxiety

Hypomanic state

Psychotic behavior/symptomatic

Queer bizarre behavior/change

Short attention span

Suicidal depression

Suicide ideation/plans

Restlessness/Anxiousness

Weight Loss

Laboratory Tests

Abnormal Lab Findings - Increased

Digoxin serum level (Lab)

Associated Diseases & Rule outs

Rule Outs

Anxiety disorder/panic attacks

Associated Disease & Complications

Drug induced Agitation/Hyperactivity/Hypomania.

Drug induced Inappropriate ADH syndrome/SIADHS

Drug induced Suicidal impulse/suicide/ideation

Dyskinesia

Hyperserotoninemia/SSRI toxicity

Hypomania

Inappropriate ADH secretion syndrome

Paranoia reaction

Parkinsonism, secondary

REM Behavior disorder/RBD

Serotonin SSRI/St Johns Wort syndrome

Suicide attempt/suicidal/suicide

Upper GI Bleeding in Elderly

Disease Mechanism & Classification

Drugs

DRUG/Antidepressant medication (examples)

DRUG/Psychoactive/sedative drug (category)

DRUG/Safe in pregnancy patient (B)

DRUG/Selective serotonin reuptake inhib/SSRI (example)

DRUG/Serotonin reuptake inhibitor/CNS effect

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

Benzenepropanamine N methyl gamma (4 (trifluoromethyl)phenoxy) (+ ), FLUOX, Fluoxetin, fluoxetine, Fluoxetine (product), Fluoxetine (substance), FLUOXETINE PREPARATION, N methyl gamma (4 (trifluoromethyl) phenoxy) benzenepropanamine, N Methyl gamma (4 (trifluoromethyl)phenoxy)benzenepropanamine, Brand name/ Symbyax (Olanzapine-Fluoxetine) combination, Brand name/Prozac (Fluoxetine), Brand name/Sarafem (Fluoxetine)

Treatment

Drug Dosage

DRUG/.$$$ Expensive medication

DRUG/.$$$$ Very Expensive

DRUG/.1990 or before

DRUG/Dose 10 mgm (Unit/Pill/Capsule size)

DRUG/Dose 20 mgm (Unit/Pill/Capsule size)

DRUG/Dose 40 mgm (Unit/Pill/Capsule size)

DRUG/Dose 80 mgms (Unit/Pill/Capsule size)

DRUG/Dose Capsule preparation/drug (ex)

DRUG/Dose liquid/syrup/suspension form

DRUG/Dose once daily (RX)

DRUG/Generic available

DRUG/Half-life 6 days

DRUG/Half-life very long (days)

DRUG/Oral medication (ex)

-Protein bound/drug

Definition

Central CNS SSRI (selective serotonin reuptake inhibitor) Drug; class of antidepressant drug restores serotonin levels to strategic synapse areas; safer than most and versatile; oral preparations

(Edit)

External Links Related to Fluoxetine (Prozac) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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