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Disease Information for Flecainide (Tambocor) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Dizzy on Standing/Giddy Response

Hypotension with Relative Bradycardia

Low Blood Pressure

Orthostatic drop in blood pressure

Slow pulse/Bradycardia

Diagnostic Test Results

EKG (ECG)

EKG/Prolonged PR Interval (ECG)

EKG/Widened QRS pattern (ECG)

EKG/AV Nodal Block/Complete

EKG/Changes/abnormalities (ECG)

Associated Diseases & Rule outs

Rule Outs

Digitalis toxicity/poisoning

Associated Disease & Complications

Bradyarrhythmias

Cardiac arrhythmias

Cardiac conduction defects

Drug induced Arrhythmias

Heart block, complete

Hypotension

Orthostatic syncope Hypotension

Torsades de pointes/ventricular tachycardia

Disease Mechanism & Classification

Drugs

DRUG/Anti-arrhythmic medication (example)

DRUG/Cardiovascular meds (examples)

DRUG/Chronic pain/Neuropathic pain adjunct medication

DRUG/Class I antiarrhythmic drug (example)

DRUG/Class IC antiarrhythmic agent (example)

DRUG/Class one/sodium channel myocardial blocker (example)

DRUG/metabolized by CYP 3A pathway

DRUG/Proarrhythmic drug effect (example)

DRUG/Sodium-channel block effect/toxicity

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Toxin

TOXIN/Hypotension relative bradycardia

Synonyms

Synonym

Benzamide N (2 piperidinylmethyl) 2,5 bis(2,2,2 trifluoroethoxy), Flecainide, Flecainide (product), Flecainide (substance), FLECAINIDE PREPARATION, Brand name/Tambocor (Flecainide)TOXIC

Treatment

Drug Dosage

DRUG/Drug discontinued/TOXIC (RX)

Definition

Anti-arrhythmic medication;Von Williams class I-C;

caused torsade de points ventricular tachycardia

and ventricular arrhythmias/deaths on CAST trials; withdrawn as toxic drug;Can be used for non-sustained

ventricular tachycardia in normal hearts.

(Edit)

External Links Related to Flecainide (Tambocor) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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