Disease Information for Exostosis, multiple

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Clinical Manifestations
Signs & Symptoms
Subcutaneous hard bony nodules
Ankle Bony Mass
Bone Mass/Local Swelling
Radius Bone Mass
Skull bony swelling
Associated Diseases & Rule outs
Rule Outs
Osteoarthritis, degenerative
Associated Disease & Complications
Exostosis
Disease Mechanism & Classification
Class
CLASS/Bone disorder (ex)
CLASS/Skeletal (category)
Pathophysiology
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Gene locus 8p (Short arm chromosome 8)
Pathophysiology/Gene locus 8q24
Pathophysiology/Gene locus chromosome 8
Process
PROCESS/Structural/anatomic/foreign body (category)
Definition

Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.

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External Links Related to Exostosis, multiple
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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