Disease Information for Erythema induratum

Clinical Manifestations
Signs & Symptoms
Bilateral ankle swelling
Bilateral leg edema/swelling
Bilateral ankle rash/purpura
Disfiguring/mutilating/scarring skin lesions
Dusky erythrocyanotic nodules calfs/ankles
Indurated lesion/base
Multifocal skin lesions
Necrotizing lesions/cold exposed areas
Nodosal lesions
Nodular rash
Nodular rash with ulcer/necrosis/scarring effect
Rash on extremities
Rash triggered by cold exposure
Rash/abdomen area
Rash/Characteristic pattern/distribution
Rash/lesions lower extremities
Rash/shin area
Residual Scars lower extremity lesions
Skin/Dermal necrosis signs
Subcutaneous/induration/anchored tissues
Symmetrical rash
Edema of Lower Extremities
Cold intolerance
Clinical Presentation & Variations
Presentation/Painful Leg Ulcer Chronic
Presentation/Young woman Indurated ulcers legs TBC case
Presentation/Chronic Painful Infected Indurated Leg
Fever and High Sed Rate
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Progressive/slowly chronic illness
Prognosis/Recovery/reversable usually
Prognosis/Slow steady recovery
Demographics & Risk Factors
Travel, Geographic & Climate Related Factors
Residence/travel/Eastern Europe/Balkans
Established Disease Population
Patient/Debilitated/chronically ill
Patient/Tuberculosis, chronic
Laboratory Tests
Microbiology & Serology Findings
Serum specific antibodies increased
Microlab/PCR TBC in specimen
Microlab/PCR/Antigen test/Abnormal
Microlab/Serol/Specific titers present
Abnormal Lab Findings (Non Measured)
Very High Sed Rate
Abnormal Lab Findings - Increased
PCR/TBC Serum Test
Sed Rate/ESR/Sedimentation rate (Lab)
Diagnostic Test Results
Other Tests & Procedures
Skin test/TB/PPD positive
PATH/Vasculitis lesions
BX/Abdominal Fat-Pad tissue biopsy/abnormal
BX/Adipose tissue biopsy/abnormal
BX/Skin biopsy/Epidermal necrosis/hemorrhage
BX/Skin biopsy/Fibrin clots/all vessels/necrosis
BX/Skin biopsy/Granuloma, non-caseating
BX/Skin/Acute Inflammation Polys
PATH/Adipose/SQ tissue vasculitis/granuloma
PATH/Skin/nodule biopsy/Necrotic granulomas/polys
PATH/Granulomatous tissue/specimen
Xray/Chest abnormal
Xray/Apical lordotic views abnormal/Chest
Xray/Chest/Lung fields/Abnormal
Associated Diseases & Rule outs
Rule Outs
Lepromatous erythema nodosum
Associated Disease & Complications
Dermatitis/Chronic rash
Erythema Induratum
Hypersensitivity angiitis
Severe/Hemorrhagic PPD response
Granulomatous Dermatitis
Leg ulcers
Disease Synergy - Causes
Synergy/Cold environment
Disease Mechanism & Classification
Specific Agent
AGENT/Endemic disease (ex)
CLASS/Capillary/microcirculation disorder (ex)
CLASS/Cardiovascular (category)
CLASS/Dermatologic/Subcutaneous (category)
CLASS/Fatty tissue/subcutaneous disorder (ex)
CLASS/Subcutaneous/Panniculus tissue disorder
Pathophysiology/Allergic-infectious agent response
Pathophysiology/Anatomically strategic lesion (ex)
Pathophysiology/Necrotizing vasculitis
Pathophysiology/Granulomatous skin areas/lesions
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Hypersensitivity reaction (ex).
PROCESS/INCIDENCE/Regional specific
PROCESS/Inflammatory/Allergy/immune (ex)
PROCESS/Inflammatory/Granulomatous disease (ex)
PROCESS/Reference organ/system (category)
PROCESS/Inflammatory/Vascular/venous/phlebitis (ex)
PROCESS/Granulomatous Disease
Bazin, BAZIN DIS, Bazin Disease, BAZINS DIS, Bazins Disease, Bazin's disease, Bazin's syndrome, Disease Bazin, Disease Bazin's, Erythema Induratum, Erythema induratum (disorder), erythema induratum tuberculous, Induration erythema, induratum erythema, induratum erythema tuberculous, Tuberculosis Cutis Indurativa, Tuberculosis cutis indurativa (disorder), Tuberculosis indurativa, Tuberculous Bazin's disease, Tuberculous erythema induratum, Synonym/Bazin's disease (TBC skin ulcers/rash), Synonym/Bazin's malady/Erythema induratum, Synonym/Bazin-TBC indurativa cutanea/subcutanea, Synonym/Erythema induratum scrophulosorum, Synonym/Nodular vasculitis syndrome, Synonym/Scrofulous ulcers of legs, Synonym/Whitfield type non TBC type/Variant erythema ind.
Drug Therapy - Indication
RX/Antituberculosis antibiotic
RX/Corticosteroid (Cortisone)
RX/Corticosteroid adjunct to antibiotics
RX/Topical Potassium Iodide solution
Surgical Procedures or Treatments
TX/Rest-Time off

A type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis; It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent; It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves; The nodules may progress to form indurations, ulcerations, and scars;

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Bazin's Erythema Induratum; Bazin's disease;Also known as: Bazin's malady; Bazin-tuberculosis indurativa cutanea et subcutanea; Erythema induratum; erythema induratum scrophulosorum, nodular vasculitis, scrofulous ulcers of the legs, tuberculosis cutis indurativa, tuberculosis indurativa cutanea et subcutanea; Description: Chronic skin disease characterized by hard cutaneous nodules that break down to form indolent necrotic ulcers leaving atrophic, pigmented scars; On the calfs, thighs, abdomen; Initially, it was considered a form of skin tuberculosis, and most frequently seen in adolescent girls and menopausal women with tuberculosis or positive tuberculin test; However, cases that appear to be unrelated to tuberculosis have been observed; Etiology still uncertain;

Erythema induratum and nodular vasculitis had been considered the same disease entity for a long time; However, nodular vasculitis is now considered a multifactorial syndrome of lobular panniculitis in which tuberculosis may or may not be one of a multitude of etiologic components; Therefore, erythema induratum/nodular vasculitis complex is classified into 2 variants: Erythema induratum of Bazin type and nodular vasculitis or erythema induratum of Whitfield type; Bazin type is related with tuberculous origin, but Whitfield type is not related.


External Links Related to Erythema induratum
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)