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Disease Information for Ergotamine (Ergotrate/Cafergot) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Regional pallor/vasospasm

Vasospasm of extremities/Signs

Nausea

Vomiting

Acroparesthesias Acral Paresthesias

Toe pains

Dysesthesias

Paresthesias

Clinical Presentation & Variations

Presentation/Angina worse

Associated Diseases & Rule outs

Associated Disease & Complications

Angina pectoris

Angina, spasm type

Angina, unstable/crescendo/intermediate syndrome

Coronary ischemia

Drug induced Angina/Coronary vasospasm

Drug induced Pleural effusion

Drug induced Stroke/Cerebral ischemia/Bleed

Ischemia, cardiac

Ischemic bowel disease

Myocardial infarction, acute

Pericardial effusion

Precipitous labor

Raynaud's syndrome

Secondary Psychosis/Symptomatic

Non-Occlusive Bowel Infarction

Disease Mechanism & Classification

Drugs

DRUG/Anti-migraine medication (example)

DRUG/metabolized by CYP 3A pathway

Pathophysiology

Pathophysiology/Myocardial Ischemia Non-Arteriosclerosis

Pathophysiology/Mesenteric Ischemia Non-Occlusive

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Toxin

TOXIN/NOT Diagnosed on USUALToxic screens

Synonyms

Synonym

Ergotaman 3',6',18 trione 12' hydroxy 2' methyl 5' (phenylmethyl) (5'alpha), Ergotamine, Ergotamine (product), Ergotamine (substance), ERGOTAMINE PREPARATION, Ergotamine product, Ergotamine product (product), Ergotamine product (substance), Brand name/Cafergot (Ergotamine-Caffeine), Brand name/Ercaf (Ergotamine-Caffeine), Brand name/Ergostat (Ergotamine), Brand name/Wigraine (Ergotamine-Caffeine)

Treatment

Drug Dosage

DRUG/Dose Given for specific effect

DRUG/Dose must be titrated to effect

DRUG/Dose Rectal enema/suppository available

DRUG/Dose single dose medication

DRUG/Oral medication (ex)

Definition

Ergot alkaloid synthetic drug;used in postpartum hemorrhage and uterine atony;oral and rectal and parenteral preparation; also used in acute migraine in combination with caffeine

(Edit)

External Links Related to Ergotamine (Ergotrate/Cafergot) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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