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Disease Information for Ergot alkaloid Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Brief Blood pressure increase/sign:

Chest Pain

Chest pain, substernal/midline

High blood pressure/sign

Leg claudication

Non-Pleuritic Chest Pain

Regional pallor/vasospasm

Sudden pallor

Vasospasm of extremities/Signs

White/blanching area discoloration

Nausea

Vomiting

Acroparesthesias Acral Paresthesias

Leg Pain with Exercise

Pain in Extremities/Melalgias

Painful hands and feet

Chest pain/non-cardiac

Chest tightness/breathing response

Pallor

Clinical Presentation & Variations

Presentation/Angina worse

Demographics & Risk Factors

Established Disease Population

Patient/Migraine headache/Migraineurs

Associated Diseases & Rule outs

Associated Disease & Complications

Angina pectoris

Angina, spasm type

Angina, unstable/crescendo/intermediate syndrome

Convulsions (grand mal)

Coronary ischemia

Drug induced Angina/Coronary vasospasm

Drug induced Seizures

Drug induced Stroke/Cerebral ischemia/Bleed

Gravid uterus tetanic contraction

Hypertension

Ischemia, cardiac

Ischemic bowel disease

Myocardial infarction, acute

Porphyria, attack, acute intermittant

Raynaud's syndrome

Sinus bradycardia

Toxic amblyopia syndrome

Non-Occlusive Bowel Infarction

Disease Mechanism & Classification

Drugs

DRUG/Anti-migraine medication (example)

DRUG/Gravid uterine contraction stimulus (example)

DRUG/Lowers seizure threshold

Pathophysiology

Pathophysiology/Myocardial Ischemia Non-Arteriosclerosis

Pathophysiology/Mesenteric Ischemia Non-Occlusive

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Toxin

TOXIN/ Hypertension/slow heart rate

TOXIN/NOT Diagnosed on USUALToxic screens

Synonyms

Synonym

Alkaloids Clavine, Alkaloids Ergot, Clavine Alkaloids, Ergot alkaloid, Ergot alkaloid (substance), Ergot alkaloid product, Ergot alkaloid product (product), Ergot alkaloid product (substance), Ergot Alkaloids, Brand name/Gynergen (Ergonovine)

Treatment

Drug Therapy - Contraindication

RX/Sumatriptan (Imitrex)

Drug Dosage

DRUG/Dose Rectal enema/suppository available

DRUG/Dose single dose medication

DRUG/Inhaled/aerosolized medication (example)

Definition

Ergot alkaloid natural or synthetic drug;used in postpartum hemorrhage and uterine atony;oral and parenteral preparation; also used in acute migraine; peripheral and coronary vasospasm can occur

(Edit)

External Links Related to Ergot alkaloid Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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