Disease Information for Epilepsia partialis continua/subclinical

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Clinical Manifestations
Signs & Symptoms
Abnormal movements/involuntary
Aphasia
CNS symptoms/signs
Delirium
Delirium/Agitated delirium
Dizziness/Dizzy
Dysarthria
Episodic light distortions
Involuntary movements
Lightheadedness/giddyness/spacey
Myoclonus/Myoclonic jerks on exam
Slow speech
Difficulty Talking
Typical Clinical Presentation
Coma with normal Head CT Scan
Disease Progression
Course/Acute
Course/Chronic disease crisis/flare/attacks
Course/Potentially lethal/untreated
Course/Recurrent
Course/Relapsing
Lethal Potential
Demographics & Risk Factors
Established Disease Population
Patient/Epilepsy
Occupational Factors
Setting/Intensive/postop/cardiac care unit
Diagnostic Test Results
Other Tests & Procedures
Lumbar puncture/Increased CSF pressure/LP test
Electrodiagnosis
EEG/Abnormality
EEG/Characteristic pattern abnormal
EEG/Seizure activity abnormality
Associated Diseases & Rule outs
Rule Outs
Cerebral vascular accident
Meningitis Bacterial
Associated Disease & Complications
Amnesia
Coma in Children
Coma/Unconscious
Death Outcome
Epilepsy partialis continua
Disease Mechanism & Classification
Class
CLASS/Brain/CNS disorder (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/CSF Pressure Increased
Pathophysiology/Epileptiform/epileptic disorder
Process
PROCESS/Partial seizure type (ex)
Synonyms
Synonym
Epilepsia Partialis Continua, Epilepsia partialis continua (disorder), Epilepsies Kojevnikov's, Epilepsy Kojevnikov's, Epilepsy Kojewnikov's, Kojevnikov Epilepsy, Kojevnikov's Epilepsies, Kojevnikov's epilepsy, Kojevnikov's epilepsy (disorder), Kojewnikoff's syndrome, Kojewnikov Epilepsy, Kojewnikov's Epilepsy, Kojewnikow Syndrome, Kojewnikow's Syndrome, Kozhevnikov Syndrome, Kozhevnikov's Syndrome, Motor simple partial status, Syndrome Kojewnikow, Syndrome Kojewnikow's, Syndrome Kozhevnikov, Syndrome Kozhevnikov's, Synonym/Epileptic Twilight States, Synonym/Spike Wave Stupor
Treatment
Drug Therapy - Indication
RX/Anticonvulsants
RX/Barbiturate
RX/Diazepam (Valium) injection (acute)
RX/Lamotrigine (Lamictal)
RX/Phenytoin
Other Treatments
TX/Ketogenic diet
TX/Restraint
Definition

A variant of epilepsy characterized by continuous focal jerking of a body part over a period of hours, days, or even years without spreading to other body regions; Contractions may be aggravated by movement and are reduced, but not abolished during sleep; ELECTROENCEPHALOGRAPHY demonstrates epileptiform (spike and wave) discharges over the hemisphere opposite to the affected limb in most instances; The repetitive movements may originate from the CEREBRAL CORTEX or from subcortical structures (e.g., BRAIN STEM; BASAL GANGLIA); This condition is associated with Russian Spring and Summer encephalitis (see ENCEPHALITIS, TICK BORNE); Rasmussen syndrome (see ENCEPHALITIS); MULTIPLE SCLEROSIS; DIABETES MELLITUS; BRAIN NEOPLASMS; and CEREBROVASCULAR DISORDERS. (From Brain, 1996 April;119(pt2):393-407; Epilepsia 1993;34;Suppl 1:S29-S36; and Adams

a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction;

Some are in COMA status with Nonconvulsive forms including petit mal status and complex partial status, which may manifest as behavioral disturbances; Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition ( EPILEPSIA PARTIALIS CONTINUA); Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity; (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)

Common in ICU/CCU patients especially in hypoxic CNS injury, those with remote seizure history, and evident ocular movement abnormalities; treatment is usually Lorazepam or other Benzodiazepines;This can be a lethal disorder

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Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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