Disease Information for Epilepsia partialis continua/subclinical

A variant of epilepsy characterized by continuous focal jerking of a body part over a period of hours, days, or even years without spreading to other body regions; Contractions may be aggravated by movement and are reduced, but not abolished during sleep; ELECTROENCEPHALOGRAPHY demonstrates epileptiform (spike and wave) discharges over the hemisphere opposite to the affected limb in most instances; The repetitive movements may originate from the CEREBRAL CORTEX or from subcortical structures (e.g., BRAIN STEM; BASAL GANGLIA); This condition is associated with Russian Spring and Summer encephalitis (see ENCEPHALITIS, TICK BORNE); Rasmussen syndrome (see ENCEPHALITIS); MULTIPLE SCLEROSIS; DIABETES MELLITUS; BRAIN NEOPLASMS; and CEREBROVASCULAR DISORDERS. (From Brain, 1996 April;119(pt2):393-407; Epilepsia 1993;34;Suppl 1:S29-S36; and Adams

a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction;

Some are in COMA status with Nonconvulsive forms including petit mal status and complex partial status, which may manifest as behavioral disturbances; Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition ( EPILEPSIA PARTIALIS CONTINUA); Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity; (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)

Common in ICU/CCU patients especially in hypoxic CNS injury, those with remote seizure history, and evident ocular movement abnormalities; treatment is usually Lorazepam or other Benzodiazepines;This can be a lethal disorder

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