Disease Information for Eosinophilic granuloma

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Clinical Manifestations
Signs & Symptoms
Adolescent
Head and Neck Soft Tissue Mass
Head and neck swelling
P2 sound accentuated
Lymphadenopathy Systemic
Proptosis,bilateral
Blocked ears feeling
Earache
Typical Clinical Presentation
Presentation/Fractures Pathologic Minimal Trauma
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Young Adult
Sex & Age Groups
Population/Adolescent
Population/Adult/all
Population/Child
Population/Children/all
Population/Young adult
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Hyperprolactinemia
Abnormal Lab Findings - Increased
Beta globulin, serum (Lab)
Globulin, serum (Lab)
Prolactin (Lab)
Diagnostic Test Results
Pathology
BX/Lung biopsy/Granulomas in lung
PATH/Langerhans' histiocyte/Immune S100 protein
PATH/Langerhans' histiocytes present
PATH/Eosinophilic infiltrate/tissue
PATH/Granulomatous tissue/specimen
X-RAY
Xray/Chest abnormal
Xray/Chest/Lung fields/Abnormal
Xray/Lung lesion/localized/Chest
Xray/Nodular lung pattern/Chest
Xray/Upper lobe lesion/Chest
Xray/Bone lesion, solitary lytic
Xray/Bone lesions, motheaten lytic multiple
Xray/Skull single lytic lesion
Xray/Destructive mass in middle ear/Head
Xray/Tympanic portion of petrous bone eroded/Skull
X-RAY With contrast
SBS/Bulls-eye lesion/gut
Associated Diseases & Rule outs
Rule Outs
Hypothalamic dysfunction
Otitis media
Otosclerosis
Associated Disease & Complications
Cor pulmonale
Deafness
Deafness, conduction type
Diabetes insipidus
Eosinophilic granuloma/hypophysis
Eustachian tube blockage/symptomatic
Exophthalmos
Hyperglobulinemia
Interstitial lung involvement/manifestation
Otitis media
Pneumothorax
Mass in Bone
Disease Mechanism & Classification
Class
CLASS/Langerhan Cell/Tissue Macrophages involvement/disorder (ex)
CLASS/Pediatric disorders (ex)
CLASS/Hypothalamus/neurohypophysis involvement (ex)
CLASS/Leukocyte involvement/disorder (ex)
CLASS/Mastoid involvement/disorder (ex)
Pathophysiology
Pathophysiology/Langerhans/histiocyte cell disease/LCD (ex)
Pathophysiology/Immunoregulatory defect/causal
Process
PROCESS/Eosinophilic syndromes (ex)
PROCESS/Inflammatory/Granulomatous disease (ex)
PROCESS/Metabolic/storage disorder (category)
PROCESS/Storage disorder (ex)
PROCESS/Proliferative/infiltrative disorder (ex)
PROCESS/Bone tumors vertebra
PROCESS/Granulomatous Disease
Synonyms
Synonym
eosinophilic granuloma, Eosinophilic granuloma (clinical), Eosinophilic granuloma RETIRED, Eosinophilic Granulomas, Eosinophilic xanthom granuloma, Eosinophilic xanthomatous granuloma, Granuloma Eosinophilic, Granulomas Eosinophilic, Synonym/Congenital Langerhans/histiocytosis
Treatment
Surgical Procedures or Treatments
SX/Biopsy
Definition

The most benign clinical form of Langerhans-cell histiocytosis (HISTIOCYTOSIS, LANGERHANS-CELL), which involves localized nodular lesions of the gastric mucosa, small intestine, bones, lungs, or skin, with infiltration by eosinophils. The proliferating cell that appears to be responsible for the clinical manifestations is the Langerhans cell.

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External Links Related to Eosinophilic granuloma
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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