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Disease Information for Ectopic ACTH producing tumor

Clinical Manifestations
Signs & Symptoms: Plethora/Red face/Ruddy look
: Acne flare; Brown skin discoloration; Bruising/Ecchymosis; Hirsutism; Hypertrichosis; Increased pigmentation/tanning/hyperpigmented; Purpura; Striae/Purple striae; Thin skin/parchment-like skin
: Buffalo hump; Moon-like facies
: Loss of libido,male; Sexual dysfunction
: Excessive/easy bruising tendency
: Muscle weakness
: Delirium; Delirium/Agitated delirium; Impaired judgement/signs
: Amenorrhea; Oligomenorrhea/Hypomenorrhea; Polymenorrhagia
: Truncal obesity; Weakness; Weight gain
Disease Progression: Course/Chronic disorder; Course/Chronic only
Demographics & Risk Factors
Established Disease Population: Patient/Small cell cancer lung
Laboratory Tests
Abnormal Lab Findings - Decreased: Chloride serum (Lab); Lymphocytes (Lab); Plasma renin Activity/PRA (Lab); Potassium, serum (Lab); Renin, serum (Lab)
Abnormal Lab Findings - Increased: SALIVA Cortisol Late Night Sample
: ACTH/Corticotrpin/Adrenocortical Hypertrophic hormone (Lab); Androstenedione (Lab); Chloride serum (Lab); Cortisol (Lab); Dehydroepiandrosterone S (DHEAS) (Lab); Sodium, serum (Lab)
: URINE 17-Hydroxycorticosteroids; URINE Cortisol/Free Cortisol; URINE Free Cortisol/24 Hour
Diagnostic Test Results
Other Tests & Procedures: Skin test anergy
: TEST/Cosyntropin IV (0.25mgm) test abnormal; TEST/Cosyntropin IV (0.25mgm) test Excess Response; TEST/Decadron suppression abnormal
EKG (ECG): EKG/Prominent U Waves (ECG)
CT Scan: CT Scan/Adrenal Mass Bilateral; MRI/Bilateral Adrenal Masses/abdomen
: CT/Dexa-Scan Bone density Abnormal
Associated Diseases & Rule outs
Associated Disease & Complications: Acne vulgaris (acne); Anergic status; Cataract/posterior type; Cellular immunity defect/deficiency; Cushing's disease/Syndrome; Ectopic ACTH production syndrome; Hyperglycemia; Hypernatremia; Hyperpigmentation; Hypertension; Hypertension, secondary; Hypokalemia; Hypokalemic nephropathy; Male osteoporosis syndrome; Metabolic encephalopathy; Orthostatic hypotension syndrome; Osteoporosis/osteopenia; Pathologic fractures; Peptic ulcer disease; Pituitary adenoma, ACTH secreting; Psychosis; Secondary hyperparathyroidism
: Hypergastrinemia
: Diabetes mellitus/non-insulin dep/type II
: Metabolic Bone Disease
Disease Mechanism & Classification
Class: CLASS/Adrenal gland disorders (ex).; CLASS/Endocrine gland (category); CLASS/Pituitary gland involvement/disorder (ex)
Pathophysiology: Pathophysiology/Paraneoplastic Endocrine Syndrome exists
: Pathophysiology/Osteoporosis Secondary
: Pathophysiology/Alkalosis Chloride Resistant
Process: PROCESS/Endocrine/humoral disorders (category); PROCESS/Neoplastic (category); PROCESS/Paraneoplastic disorder (ex); PROCESS/Vegetative-Autonomic/Endocrine (category)
: PROCESS/Tumors/ectopic endocrine/hormones release (ex)
Treatment
Drug Therapy - Contraindication: RX/Corticosteroid (Cortisone)
Drug Therapy - Indication: RX/Aminoglutethimide (Cytadren); RX/Ketoconazole (Nizoral); RX/Metyrapone (Metopirone); RX/Potassium
Surgical Procedures or Treatments: SX/Surgery
Definition: Be the first to add a definition for Ectopic ACTH producing tumor
External Links Related to Ectopic ACTH producing tumor: Google; Wikipedia; Merck; Images; PubMed (National Library of Medicine); NGC (National Guideline Clearinghouse); Medscape (eMedicine); Harrison's Online (accessmedicine); NEJM (The New England Journal of Medicine)

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