Disease Information for Duchenne's Muscular Dystrophy/Pseudohypertrophic

Synonyms:

adult pseudohypertrophic muscular dystrophy, benign X linked recessive muscular dystrophy, CARDIOMYOPATHY DILATED 3B, CARDIOMYOPATHY DILATED X LINKED, Childhood Muscular Dystrophy Pseudohypertrophic, Childhood Pseudohypertrophic Muscular Dystrophy, classic X linked recessive muscular dystrophy, CMD3B, DMD, DMD Duchenne muscul dystroph, DMD Duchenne muscular dystrophy, Duchenne de Boulogne muscular dystrophy, Duchenne dystrophy, Duchenne Griesinger, Duchenne Griesinger syndrome, Duchenne motor neuron disease, Duchenne musc dyst, Duchenne muscular dystrophy, Duchenne muscular dystrophy (disorder), Duchenne muscular dystrophy (DMD), Duchenne myodystrophy, Duchenne pseudohypertrophic muscular dystrophy, Duchenne syndrome, Duchenne type dystrophy, Duchenne Type Progressive Muscular Dystrophy, Duchenne's Muscular Dystrophy, Dystrophies Pseudohypertrophic Muscular, Dystrophy Duchenne Muscular, dystrophy Duchenne type, dystrophy muscular Duchenne type, Dystrophy Pseudohypertrophic Muscular, mild X linked recessive muscular dystrophy, motor neuron Duchenne, Muscular Dystrophies Pseudohypertrophic, Muscular Dystrophy Childhood Pseudohypertrophic, MUSCULAR DYSTROPHY DUCHENNE, MUSCULAR DYSTROPHY DUCHENNE TYPE, Muscular Dystrophy Pseudohypertrophic, Muscular Dystrophy Pseudohypertrophic Childhood, MUSCULAR DYSTROPHY PSEUDOHYPERTROPHIC PROGRESSIVE DUCHENNE TYPE, progressive muscular dystrophy Duchenne type, progressive muscular dystrophy of childhood, pseudohypertrophic adult muscular dystrophy, Pseudohypertrophic Childhood Muscular Dystrophy, Pseudohypertrophic Muscular Dystrophies, Pseudohypertrophic Muscular Dystrophy, Pseudohypertrophic Muscular Dystrophy Childhood, pseudohypertrophic muscular paralysis, pseudohypertrophic progressive muscular dystrophy, pseudohypertrophic progressive muscular dystrophy Duchenne type, Pseudohypertrph musc dystrophy, Severe generalized familial muscular dystrophy, X linked dilated cardiomyopathy, X linked dilated cardiomyopathy (XLCM), X linked muscular dystrophy, X linked recessive muscular dystrophy, XLCM

(less)

adult pseudohypertrophic muscular dystrophy, benign X linked recessive musc... (more)

Definition:

Muscular Dystrophy, Duchenne; Childhood Muscular Dystrophy; DMD; Muscular Dystrophy, Classic X-linked Recessive; Progressive Muscular Dystrophy of Childhood; Pseudohypertrophic Muscular Dystrophy; Duchenne Muscular Dystrophy, a hereditary degenerative disease of skeletal (voluntary) muscles, is considered the most prevalent form of childhood muscular dystrophy; The disorder typically is recognized from approximately age three to six years and has a relatively rapid, progressive disease course; Duchenne Muscular Dystrophy is initially characterized by muscle weakness and wasting (atrophy) within the pelvic area that may be followed by involvement of the shoulder muscles; With disease progression, muscle weakness and atrophy affect the trunk and forearms and gradually progress to involve most major muscles of the body; In individuals with the disorder, initial findings may include an unusual, waddling manner of walking (gait); difficulty climbing stairs or rising from a sitting position; and repeated falling; With disease progression, additional abnormalities may develop, such as progressive curvature of the spine; wasting of thigh muscles and abnormal enlargement of the calves due to degenerative changes of muscle fibers (pseudohypertrophy); and abnormal fixation of certain joints (joint contractures) due to muscle weakness, prolonged immobility, and shortening of muscle fibers; By approximately age 10 to 12, most affected individuals require the use of a wheelchair; Duchenne Muscular Dystrophy is also typically characterized by additional abnormalities, including involvement of heart muscle (cardiomyopathy) and varying degrees of intellectual impairment; Affected individuals may develop an increased susceptibility to respiratory infections (eg, pneumonia), respiratory failure, impaired ability of the heart to pump blood effectively (heart failure), or other serious findings, leading to potentially life-threatening complications by late adolescence or early adulthood; Duchenne Muscular Dystrophy is caused by changes (mutations) of a gene on the short arm (p) of chromosome X (Xp21_2); The gene regulates the production of a protein that is found in skeletal and cardiac muscle; Known as dystrophin, the protein is thought to play an important role in maintaining the structure of these muscle cells; In most affected individuals, Duchenne Muscular Dystrophy is inherited as an X-linked recessive trait; Therefore, the disorder is usually fully expressed in males only; However, in rare instances, females who carry a copy of the mutated gene (heterozygous carriers) may develop certain, typically milder symptoms associated with the disorder; In addition, for some individuals with Duchenne Muscular Dystrophy, there is no family history of the disease; In such cases, the disorder may be caused by new (sporadic) genetic mutations that occur for unknown reasons---------[NORD 2005]--------

(less) (edit)

Muscular Dystrophy, Duchenne; Childhood Muscular Dystrophy; DMD; Muscular D... (more) (edit)

154 related Findings found. Compare "Duchenne's Muscular Dystrophy/Pseudohypertrophic" to ...?

Free DiagnosisPro Mobile Edition For iPhone, Handheld Devices And Most Cell Phones

What is DiagnosisPro?

DiagnosisPro is a free, accurate and time saving differential diagnosis tool that reminds you instantly of diagnostic possibilities and minimizes medical errors.

Overview

  • Covering over 15,000 disease manifestations such as symptoms, labs, ECG, X-ray, CT-Scan, MRI, Ultrasound, pathology, microbiology results and more.
  • Compiled from hundreds of world's most respected medical resources covering internal medicine, emergency medicine, pediatrics, office OB-GYN and more.
  • Designed for physicians by physicians to enhance quality of care and prevent diagnostic errors.
  • Detailed disease information for more than 7000 diseases.
  • Disease comparison tool to compare any two diseases side by side.

Join Our Community

Suggest improvement to our data or add your interesting cases to share with tens of thousands of other physicians worldwide.

AddThis Social Bookmark Button

This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.

This site is designed primarily as a reminder system for use by qualified physicians and other medical professionals. By using this site you understand and accept that DiagnosisPro.com shall not be used as a diagnostic decision-making system and must not be used to make a clinical diagnosis or replace or overrule a licensed health care professional's judgment or clinical diagnosis (full terms of use).

© 2008 MedTech USA, Inc. (last modified on 11/21/08)