Disease Information for Duane retraction syndrome

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Clinical Manifestations
Signs & Symptoms
Head tilted back/posture sign
Squint/sign
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Child
Population/Children/all
Disease Mechanism & Classification
Class
CLASS/Eye involvement/disorder (ex)
Pathophysiology
Pathophysiology/Gene locus 8q13
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Gene locus chromosome 8
Process
PROCESS/Eponymic (category)
PROCESS/Hereditofamilial (category)
PROCESS/INCIDENCE/Esoteric disease (example)
Definition

retraction syndrome/ strabismus vertical squint gene locus 8q13; facial cant on direct gaze; adductor lid closure and abductor lid opening excess;--------------------Duane syndrome is a congenital ocular motility disorder characterized by limited abduction and/or limited adduction; The palpebral fissure narrows (the globe retracts) on attempted adduction; Upward or downward deviation may occur with attempted adduction due to a leash effect; Often associated with this condition is a “tether” phenomenon consisting of overelevation, overdepression, or both, in adduction as the retracted globe escapes from its horizontal rectus restrictions; It is a condition of aberrant innervation that results in co-contraction of the medial and lateral recti in the affected eye; Thus, Duane syndrome can be considered to be a congenital miswiring of the medial and the lateral rectus muscles such that globe retraction occurs on adduction;

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External Links Related to Duane retraction syndrome
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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