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Disease Information for Drotrecogin/Activated Protein C (Xigris) Administration/Toxicity

Associated Diseases & Rule outs

Associated Disease & Complications

Bleeding complications/Surgery

Bleeding diathesis/hemorrhagic diathesis

Bleeding Tendency

Cerebral hemorrhage

Drug induced Bleeding/hemorrhagic complication

Disease Mechanism & Classification

Drugs

DRUG/ Source rDNA Manufacture

DRUG/Anticoagulant medications (examples)

DRUG/Cytokines genetically bioengineered medication (example)

DRUG/Genetically engineered/biological drug (example)

DRUG/Intensivist (ICU care)

DRUG/Specialized usage (example)

DRUG/Anti-Septicemic Shock Medication

DRUG/Human Activated Protein C/recombinant

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

Calcium Activated Phospholipid Dependent Kinase, Calcium Phospholipid Dependent Protein Kinase, Calcium phospholipid protein kinase, Phospholipid Dependent Kinase Calcium Activated, Phospholipid Sensitive Calcium Dependent Protein Kinase, PKC, PKC Serine Threonine Kinase, Protein kinase c, Protein kinase c (substance), Serine Threonine Kinase PKC, Brand name/Xigris (Activated Protein C), Synonym/Drotrecogin alfa (Xigris/Protein C activated)

Treatment

Drug Dosage

DRUG/.$$$$$ Most Expensive

DRUG/2002 new drug (RX)

DRUG/Dose special schedule/course

DRUG/Dose Unit dose Vial preparation

DRUG/Injectable medication (parenteral)

DRUG/Injectable preparation only

DRUG/Intravenous administraton RX

DRUG/Intravenous only RX

Definition

Recombinant Activated Protein C Injection/infusion used in overwhelming sepsis and septic shock; beware bleeding complications;expensive so use of protocols recommended

(Edit)

External Links Related to Drotrecogin/Activated Protein C (Xigris) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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