Disease Information for Drotrecogin/Activated Protein C (Xigris) Administration/Toxicity

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Associated Diseases & Rule outs
Associated Disease & Complications
Bleeding complications/Surgery
Bleeding diathesis/hemorrhagic diathesis
Bleeding Tendency
Cerebral hemorrhage
Drug induced Bleeding/hemorrhagic complication
Disease Mechanism & Classification
Drugs
DRUG/ Source rDNA Manufacture
DRUG/Anticoagulant medications (examples)
DRUG/Cytokines genetically bioengineered medication (example)
DRUG/Genetically engineered/biological drug (example)
DRUG/Intensivist (ICU care)
DRUG/Specialized usage (example)
DRUG/Anti-Septicemic Shock Medication
DRUG/Human Activated Protein C/recombinant
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
Calcium Activated Phospholipid Dependent Kinase, Calcium Phospholipid Dependent Protein Kinase, Calcium phospholipid protein kinase, Phospholipid Dependent Kinase Calcium Activated, Phospholipid Sensitive Calcium Dependent Protein Kinase, PKC, PKC Serine Threonine Kinase, Protein kinase c, Protein kinase c (substance), Serine Threonine Kinase PKC, Brand name/Xigris (Activated Protein C), Synonym/Drotrecogin alfa (Xigris/Protein C activated)
Treatment
Drug Dosage
DRUG/.$$$$$ Most Expensive
DRUG/2002 new drug (RX)
DRUG/Dose special schedule/course
DRUG/Dose Unit dose Vial preparation
DRUG/Injectable medication (parenteral)
DRUG/Injectable preparation only
DRUG/Intravenous administraton RX
DRUG/Intravenous only RX
Definition

Recombinant Activated Protein C Injection/infusion used in overwhelming sepsis and septic shock; beware bleeding complications;expensive so use of protocols recommended

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External Links Related to Drotrecogin/Activated Protein C (Xigris) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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