Disease Information for Disulfiram (Antabuse) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Plethora/Red face/Ruddy look
Brief Blood pressure increase/sign:
Dizzy on Standing/Giddy Response
High blood pressure/sign
Orthostatic drop in blood pressure
Red/erythema skin discoloration
Tachycardia/Fast heart rate
Alcohol induced Flushing
Cold clammy skin
Erythroderma
Facial erythema
Facial flushing/Beet red
Flushing
Flushing/upper body
Yellow skin discoloration
Impotence, relative
Nausea
Vomiting
Apathy/Indifference
Clumsiness/poor coordination
Confusion/Disoriented
Delirium
Delirium/Agitated delirium
Fine-motor coordination problems
Lethargy/torpor
Motor and sensory neuropathy/Polyneuropathy signs
Paresthesias
Poor coordination legs/feet
Seizures
Stupor/poor reponse to stimulus
Manic behavior
Bone Pain Triggered by Alcohol
Bone Pains
Certain drugs trigger rash/flushing/itch
Cold clammy pale status
Collapse/Prostration
Listlessness/lassitude
Laboratory Tests
Abnormal Lab Findings - Decreased
Norepinephrine, plasma (Lab)
Associated Diseases & Rule outs
Rule Outs
Guillain-Barre syndrome
Associated Disease & Complications
Convulsions (grand mal)
Disufiram (Antabuse) effect/toxicity
Disulfiram-like drug reaction/alcohol
Drug induced Impotence.
Drug induced Peripheral neuropathy.
Fetal anomaly
Hypertension
Impotence/Erectile dysfunction disorder
Orthostatic syncope Hypotension
Peripheral neuropathy
Polyneuritis
Psychosis
Sedation/torpor induced
Toxic hepatitis
Toxic peripheral/polyneuropathy
Polyneuropathy
Disease Mechanism & Classification
Drugs
DRUG/Anti-addiction medication (example)
DRUG/Inhibits acetaldehyde catabolism/oxidation
DRUG/Inhibits Dopamine betahydroxylase/Norepinephrine production
DRUG/Specialized usage (example)
DRUG/Teratogenic potential/effect (D plus )
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/CNS depression
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Causes Flushing/Redness
TOXIN/Latency after exposure/ingestion
TOXIN/Lethal possible
TOXIN/Slow curve fast break 24 hrs
Synonyms
Synonym
Antabus effect, Antabuse effect, Brand name/Antabuse (Disulfiram)
Treatment
Drug Therapy - Contraindication
RX/Ethanol (Eythyl alcohol) infusion
RX/Warfarin (Coumadin)
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 250 mgm (Unit/Pill/Capsule size)
DRUG/Dose 500 mgm (Unit/Pill/Capsule size)
DRUG/Dose once daily (RX)
DRUG/Generic available
DRUG/Oral medication (ex)
Definition

Specialized drug; alcohol addiction drug; inhibits alcohol

metabolism build up acetaldehyde levels highly symptomatic; oral preparation

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External Links Related to Disulfiram (Antabuse) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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