Disease Information for Diphenhydramine (Benadryl) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Tachycardia/Fast heart rate
Decreased sweating/Absent sweating
Decreased salivation
Dry mouth/Mucous membranes
Confusion/Disoriented
Delirium
Delirium/Agitated delirium
Relaxed/tranquilized feeling
Seizures
Stupor/poor reponse to stimulus
Manic behavior
Fatigue Tiredness in Elderly
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Dry eyes/poor tearing
Dry eyes/Poor tearing in Children
Dryness Conjunctiva
Grainy/Gritty Eye Sensation
Mydriasis/wide pupils
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Abnormal Lab Findings - Decreased
PT -Prothrombin time (Lab)
Diagnostic Test Results
Isotope Scan
Isotope/RAI uptake/quantitative high thyroid (I 123)
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Anhydrosis/Absent sweating/diffuse
Anticholinergic/belladonna group toxidrome
Convulsions (grand mal)
Drug induced Sedation/torpor
Hyperpyrexia
Hyperthermia
Sedation/torpor induced
Xerophthalmia
Disease Mechanism & Classification
Drugs
DRUG/Anticholinergics effect/toxicity
DRUG/Antiemetic medication (examples)
DRUG/Antihistamine medication (examples)
DRUG/Anti-parkinsons medication (examples)
DRUG/Anti-pruritic/sedative oral (example)
DRUG/Anti-vertigo/Motion sickness medication (ex)
DRUG/Local anesthetic agent (ex)
DRUG/Safe in pregnancy patient (B)
DRUG/Sodium-channel block effect/toxicity
DRUG/Lowers seizure threshold
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Causes Hyperthermia/Fever
TOXIN/Increases Heart Rate
Synonyms
Synonym
2 Diphenylmethoxy N,N dimethylethylamine, Benhydramin, Benzhydramine, diphenhydrAMINE, Diphenhydramine (dup) (substance), Diphenhydramine (product), Diphenhydramine (substance), DIPHENHYDRAMINE PREPARATION, Diphenhydramine product, Diphenylhydramin, Diphenylhydramine, Ethanamine 2 (diphenylmethoxy) N,N dimethyl, Brand name/Allemix (Diphenhydramine), Brand name/Allerdryl (Diphenhydramine), Brand name/Allermax (Diphenhydramine), Brand name/Banaril (Diphenhydramine), Brand name/Benadryl (Diphenhydramine), Brand name/Dytuss (Diphenhydramine), Brand name/Sominex (Diphenhydramine), Brand name/Truxadryl (Diphenhydramine), Brand name/Tusstat (Diphenhydramine)
Treatment
Drug Therapy - Indication
RX/Physostigmine
Drug Dosage
DRUG/Dose 12.5 mgms (Unit/Pill/Capsule size)
DRUG/Dose 25 mgm (Unit/Pill/Capsule size)
DRUG/Dose 50 mgm (Unit/Pill/Capsule size)
DRUG/Dose Chewable form
DRUG/Dose liquid/syrup/suspension form
DRUG/Dose Multi-dose Vial preparation
DRUG/Dose Q4 hrs Medication
DRUG/Dose Q6 hrs Medication
DRUG/Dose QID Medication
DRUG/Injectable medication (parenteral)
DRUG/Intolerance in elderly/caution
DRUG/Intramuscular injection RX
DRUG/Intravenous administraton RX
DRUG/Oral medication (ex)
DRUG/Over the counter/OTC/Non-prescription
Definition

Antihistamine medication; oral preparation only; older medication; causes drowsiness, delirium, EKG QRS prolonged on overdose; Some anticholinergic effects; first drug developed in this class

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External Links Related to Diphenhydramine (Benadryl) Administration/Toxicity
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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