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- Disease Information
- Disease Comparison
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Disease Information for Diphenhydramine (Benadryl) Administration/Toxicity
- Clinical Manifestations
- Signs & Symptoms
- Tachycardia/Fast heart rate
- Decreased sweating/Absent sweating
- Decreased salivation
- Dry mouth/Mucous membranes
- Confusion/Disoriented
- Delirium
- Delirium/Agitated delirium
- Relaxed/tranquilized feeling
- Seizures
- Stupor/poor reponse to stimulus
- Manic behavior
- Fatigue Tiredness in Elderly
- Fever
- Fever Febrile Possible
- Flu-Like Syndrome
- High body temperature
- Dry eyes/poor tearing
- Dry eyes/Poor tearing in Children
- Dryness Conjunctiva
- Grainy/Gritty Eye Sensation
- Mydriasis/wide pupils
- Laboratory Tests
- Abnormal Lab Findings (Non Measured)
- Acute inflammatory markers elevated (Lab)
- Abnormal Lab Findings - Decreased
- PT -Prothrombin time (Lab)
- Diagnostic Test Results
- Isotope Scan
- Isotope/RAI uptake/quantitative high thyroid (I 123)
- EKG (ECG)
- EKG/Widened QRS pattern (ECG)
- EKG/Changes/abnormalities (ECG)
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Anhydrosis/Absent sweating/diffuse
- Anticholinergic/belladonna group toxidrome
- Convulsions (grand mal)
- Drug induced Sedation/torpor
- Hyperpyrexia
- Hyperthermia
- Sedation/torpor induced
- Xerophthalmia
- Disease Mechanism & Classification
- Drugs
- DRUG/Anticholinergics effect/toxicity
- DRUG/Antiemetic medication (examples)
- DRUG/Antihistamine medication (examples)
- DRUG/Anti-parkinsons medication (examples)
- DRUG/Anti-pruritic/sedative oral (example)
- DRUG/Anti-vertigo/Motion sickness medication (ex)
- DRUG/Local anesthetic agent (ex)
- DRUG/Safe in pregnancy patient (B)
- DRUG/Sodium-channel block effect/toxicity
- DRUG/Lowers seizure threshold
- Process
- PROCESS/Medication/Drug (CONFIRM dose/before treatment)
- Toxin
- TOXIN/Causes Hyperthermia/Fever
- TOXIN/Increases Heart Rate
- Synonyms
- Synonym
- 2 Diphenylmethoxy N,N dimethylethylamine, Benhydramin, Benzhydramine, diphenhydrAMINE, Diphenhydramine (dup) (substance), Diphenhydramine (product), Diphenhydramine (substance), DIPHENHYDRAMINE PREPARATION, Diphenhydramine product, Diphenylhydramin, Diphenylhydramine, Ethanamine 2 (diphenylmethoxy) N,N dimethyl, Brand name/Allemix (Diphenhydramine), Brand name/Allerdryl (Diphenhydramine), Brand name/Allermax (Diphenhydramine), Brand name/Banaril (Diphenhydramine), Brand name/Benadryl (Diphenhydramine), Brand name/Dytuss (Diphenhydramine), Brand name/Sominex (Diphenhydramine), Brand name/Truxadryl (Diphenhydramine), Brand name/Tusstat (Diphenhydramine)
- Treatment
- Drug Therapy - Indication
- RX/Physostigmine
- Drug Dosage
- DRUG/Dose 12.5 mgms (Unit/Pill/Capsule size)
- DRUG/Dose 25 mgm (Unit/Pill/Capsule size)
- DRUG/Dose 50 mgm (Unit/Pill/Capsule size)
- DRUG/Dose Chewable form
- DRUG/Dose liquid/syrup/suspension form
- DRUG/Dose Multi-dose Vial preparation
- DRUG/Dose Q4 hrs Medication
- DRUG/Dose Q6 hrs Medication
- DRUG/Dose QID Medication
- DRUG/Injectable medication (parenteral)
- DRUG/Intolerance in elderly/caution
- DRUG/Intramuscular injection RX
- DRUG/Intravenous administraton RX
- DRUG/Oral medication (ex)
- DRUG/Over the counter/OTC/Non-prescription
- Definition
-
Antihistamine medication; oral preparation only; older medication; causes drowsiness, delirium, EKG QRS prolonged on overdose; Some anticholinergic effects; first drug developed in this class
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- External Links Related to Diphenhydramine (Benadryl) Administration/Toxicity
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)