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Disease Information for Diltiazem (Cardizem) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Hypotension with Relative Bradycardia

Low Blood Pressure

Flushing

Rash

Diagnostic Test Results

EKG (ECG)

EKG/Widened QRS pattern (ECG)

EKG/AV Nodal Block/Complete

EKG/Sinus bradycardia (ECG)

EKG/Changes/abnormalities (ECG)

Associated Diseases & Rule outs

Rule Outs

Digitalis toxicity/poisoning

Associated Disease & Complications

Bradyarrhythmias

Cardiac conduction defects

Congestive heart failure

Drug induced Photosensitivity rash

Drug rash/Drug induced rash

Heart block, complete

Hypotension

Photosensitivity dermatitis

Phototoxicity

Pulmonary edema

Sinus bradycardia

Disease Synergy - Causes

Synergy/Congestive heart failure

Disease Mechanism & Classification

Drugs

DRUG/Anti-anginal medication (example)

DRUG/Anti-arrhythmic medication (example)

DRUG/Antihypertensive medication (examples)

DRUG/Calcium-channel blocker meds (examples)

DRUG/Cardiovascular meds (examples)

DRUG/Class IV antiarrhythmic agent (example)

DRUG/Cytochrome p450 CYP3A Pathway

DRUG/Cytochrome p450 degradation/pharmacology (ex)

DRUG/Important Acute care drugs (example)

DRUG/Non-dihydropyridine calcium channel blocker (ex)

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Toxin

TOXIN/Decreases Blood Pressure

TOXIN/Decreases Heart Rate

TOXIN/Hypotension relative bradycardia

TOXIN/Inotropic decrease/shock (ex)

Synonyms

Synonym

1,5 Benzothiazepin 4(5H) one 3 (acetyloxy) 5 (2 (dimethylamino)ethyl) 2,3 dihydro 2 (4 methoxyphenyl) (2S cis), diltiazem, Diltiazem (product), Diltiazem (substance), DILTIAZEM PREPARATION, Brand name/Cardizem (Diltiazem), Brand name/Cartia SR (Diltiazem), Brand name/Dilacor (Diltiazem), Brand name/Diltia XT (Diltiazem), Brand name/Teczem (Enalapril-Diltiazem), Brand name/Tiamate (Diltiazem), Brand name/Tiazac (Diltiazem), Brand name/Vasocardol (Diltiazem)

Treatment

Drug Therapy - Indication

RX/Calcium chloride injection/infusion

RX/Calcium gluconate infusion

RX/Glucagon

Drug Dosage

DRUG/Dose 180 mgms (Unit/Pill/Capsule size)

DRUG/Dose 240 mgms (Unit/Pill/Capsule size)

DRUG/Dose 60 mgm (Unit/Pill/Capsule size)

DRUG/Dose Extended time release/XT/SA (example)

DRUG/Dose Infusion mix 125 mgm/125 ml (CONFIRM this)

DRUG/Dose may repeat

DRUG/Infusion option medication

DRUG/Injectable medication (parenteral)

DRUG/Intravenous administraton RX

DRUG/IV requires lesser dose/Caution

DRUG/Oral medication (ex)

Definition

Calcium channel blocker medication; Cardiovascular drugs with selective and varied anti-vasospasm, hypertension, angina, and anti-arrhythmia activity; Diltiazem is used for atrial arrhythmia control; Oral and parenteral drug

(Edit)

External Links Related to Diltiazem (Cardizem) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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