Disease Information for Dihydroergotamine (DHE) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Chest Pain
Chest pain, substernal/midline
Non-Pleuritic Chest Pain
Regional pallor/vasospasm
Vasospasm of extremities/Signs
Chest tightness/breathing response
Disease Mechanism & Classification
Drugs
DRUG/Anti-migraine medication (example)
DRUG/Ergot derivative/congener (example)
DRUG/metabolized by CYP 3A pathway
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
DIHYDROERGOTAMINE, Dihydroergotamine (product), Dihydroergotamine (substance), DIHYDROERGOTAMINE PREPARATION, Dihydroergotamine product, Dihydroergotamine product (product), Dihydroergotamine product (substance), Ergotaman 3',6',18 trione 9,10 dihydro 12' hydroxy 2' methyl 5' (phenylmethyl) (5'alpha,10alpha), Brand name/DHE (Dihydroergotamine), Brand name/Migranal (Dihydroergotamine) nasal spray
Treatment
Drug Dosage
DRUG/Dose Given for specific effect
DRUG/Dose single dose medication
DRUG/Injectable medication (parenteral)
DRUG/Intramuscular injection RX
DRUG/Intranasal administration RX
DRUG/Intravenous administraton RX
Definition

Synthetic Ergot alkaloid;Anti-migraine injection/infusion therapy for acute migraine; Also as nasal spray for acute migraine;Derivative of ergotamine medications may cause vasospasm, worsening angina, and problems with hypertension

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External Links Related to Dihydroergotamine (DHE) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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