Disease Information for Diabetes mellitus/juvenile (Type I)

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Clinical Manifestations
Signs & Symptoms
Pruritis Itching
Accelerated growth Child
Anorexia in Infant
Diarrhea
Excessive thirst/polydipsia
Failure to Thrive
Failure to Thrive Child
Failure to thrive/infant sign
Feeding/Apetite Problems Child
Nausea
Polyphagia
Vomiting
Salivary Gland Enlargement
Cramping in Extremities
Muscle cramps/spasms
Weak/Weak as a kitten (symptom)
Headache
Paresthesias
Spasms in Both Legs
Tall child
Diuresis/Large urine volumes
Polyuria
Polyuria and polydipsia
Chronic Fatigue
Enervated/extreme acute fatigue
School/job performance decline
Short stature
Short stature Child
Thirst Increased
Weakness
Weakness non-neuromuscular/systemic
Weight Loss
Visual acuity decreasing
Visual symptoms
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Established Disease Population
Patient/Autoimmune disorder
Patient/Sepsis
Patient/Type I/diabetic (juvenile)
Population Group
Child
Population/Pediatrics population
Family History
Family history/Diabetes mellitus
Sex & Age Groups
Population/Child
Population/Children/all
Population/Old child
Laboratory Tests
Abnormal Lab Findings (Non Measured)
DNATest specific/genetics laboratory/abnormality (Lab)
Serum lipids increased (Lab)
HLA B27 (Lab)
Abnormal Lab Findings - Decreased
Insulin C-Peptide type, serum (Lab)
Insulin level (Lab)
Abnormal Lab Findings - Increased
Anti-GAD antibodies
Anti-Glutamic Acid decarboxylase antibodies/GAD
Anti-insulin antibodies
Anti-parietal cell antibody (Lab)
Anti-Pancreatic islet cell (512) antibodies
Anti-Islet cell Antibodies
Glucose, blood (Lab)
Glutamic Acid Dehydrogenase Antibodies/Anti-GAD (Lab)
Postprandial Glucose
URINE Glucose
Diagnostic Test Results
Other Tests & Procedures
TEST/Glucose intolerance/GTT abnormal
X-RAY
Xray/Delayed bone age/slow epiphysis closures
Associated Diseases & Rule outs
Associated Disease & Complications
Diabetic autonomic neuropathy syndrome
Diabetic ketoacidosis/coma
Hyperglycemia
Hyperlipidemia
Retinopathy
Skin infections
Diabetes mellitus/juvenile (Type I)
Disease Synergy - Causes
Synergy/Carbohydrate excess/diet
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Pancreas/accessory (category)
Pathophysiology
Pathophysiology/Cytokine gene polymorphism
Pathophysiology/Gene locus 12q24.2
Pathophysiology/Gene locus 1p13
Pathophysiology/Gene locus 6p21.3
Pathophysiology/Gene locus Chromosome 1
Pathophysiology/Gene locus chromosome 12
Pathophysiology/Gene locus Chromosome 6
Pathophysiology/Gene locus Chromosome X.
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Gene locus Xp11.23-q13.3
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Hyperglycemia/reactive/AM/Smolgi
Pathophysiology/Islets of Langerhans involvement
Process
PROCESS/Autoimmune disorder (ex)
PROCESS/Endocrine/humoral disorders (category)
PROCESS/Metabolic/storage disorder (category)
PROCESS/Systemic illness (ex)
Synonyms
Synonym
Diab mell +comp juvenile, Diabetes mellitus juvenile type + unspecified complication, Diabetes mellitus juvenile type with unspecified complication, Diabetes mellitus juvenile type with unspecified complication (disorder), Insulin dependent diabetes mellitus with unspecified complications, Type 1 diabetes mellitus with unspecified complication, Type I diabetes mellitus with complication, Type I diabetes mellitus with complication (disorder), Type I diabetes mellitus with unspecified complication, Synonym/LADA (Late autoimmune Diabetes adult) variant
Treatment
Drug Therapy - Indication
RX/Insulin
Other Treatments
TX/Diet restriction treatment.
TX/Potential Stem Cell Research RX
Definition

Autoimmune/post-infectious/genetic cause of islet beta cell wipeout causing zero output of insulin; treatment requires constant low dose insulin else brittle effect; juvenile onset and different phyasiology from type II DM where insulin levels are high not absent but insulin resistance obtains; acidosis is reguar event with type I rare in type II but much overlap; oral drugs not really effective

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External Links Related to Diabetes mellitus/juvenile (Type I)
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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