Disease Information for Dermatofibrosarcoma Protruberans

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Clinical Manifestations
Signs & Symptoms
Painful subcutaneous nodules
Skin nodules/Subcutaneous nodules
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Mild illness
Prognosis/Full recovery usual
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Cells/Tissue CD34 Positive
Diagnostic Test Results
Pathology
BX/Skin biopsy/Abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Dermatofibroma
Dermatofibrosarcoma Protruberans
Sarcomas/soft-tissue/others
Spindle cell tumor/sarcoma
Disease Mechanism & Classification
Class
CLASS/Fibroblast Fibrocyte
CLASS/Dermatologic/Subcutaneous (category)
Pathophysiology
Pathophysiology/Chromosomal translocation
Pathophysiology/Gene locus Chromosome 17
Pathophysiology/Gene locus chromosome 22
Pathophysiology/Metastasis slow-growing resectable
Pathophysiology/COL1A1/PDGFB translocation
Pathophysiology/Collagen gene (COL1A1) Mutation translocation
Pathophysiology/False Collagen Becomes PDGFB
Pathophysiology/Gene locus 17/22 translocation
Pathophysiology/PDGFR (platelet derived Growth factor receptor) expression
Pathophysiology/Somatic mutation Tumor Tissue
Process
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Malignancy/cancer (ex)
PROCESS/Neoplastic (category)
PROCESS/Sarcoma (ex)
PROCESS/Sarcoma/Fair Prognosis/No Metastasis usually
PROCESS/Somatic mutation/not hereditary
Synonyms
Synonym
Dermatofibroma protuberans, Dermatofibrosarcom protuberans, Dermatofibrosarcoma, Dermatofibrosarcoma protuberans, Dermatofibrosarcoma protuberans (disorder), DFSP, DFSP Dermatofibrosarc protru, DFSP Dermatofibrosarcoma protruberans, PDGFB COL1A1 FUSION, protuberans dermatofibrosarcoma, Synonym/DFSP
Treatment
Drug Therapy - Indication
RX/Chemotherapy(cancer)
RX/Imatinib (Gleevec/Glivec)
Surgical Procedures or Treatments
SX/Biopsy
SX/Surgery
SX/MOHS Micrographic Surgery
Other Treatments
TX/Radiotherapy.
Definition
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External Links Related to Dermatofibrosarcoma Protruberans
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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