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Disease Information for Demeclocycline (Declomycin) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Rash

Laboratory Tests

Abnormal Lab Findings (Non Measured)

URINE Isosthenuria/mid-range SPGR

URINE Specific gravity fixed/1.010

Abnormal Lab Findings - Decreased

ADH/Antidiuretic Hormone/Vasopressin/Oxytocin level (Lab)

Abnormal Lab Findings - Increased

ADH/Antidiuretic Hormone/Vasopressin/Oxytocin level (Lab)

Sodium, serum (Lab)

Diagnostic Test Results

Isotope Scan

Isotope/RAI uptake/quantitative high thyroid (I 123)

Associated Diseases & Rule outs

Rule Outs

Diabetes insipidus

Associated Disease & Complications

Acquired Diabetes Insipidus

Demeclocycline (Declomycin) effect/toxicity

Diabetes insipidus

Drug induced Hypernatremia

Drug induced Photosensitivity rash

Drug rash/Drug induced rash

Hypernatremia

Hyperosmolar state

Isosthenuria syndrome

Nephrogenic diabetes insipidus

Photosensitivity dermatitis

Phototoxicity

Disease Mechanism & Classification

Drugs

DRUG/Antibiotic/Antimicrobial drugs (category)

DRUG/Tetracycline antibiotic (example)

Pathophysiology

Pathophysiology/Renal concentration capacity defect

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

2 Naphthacenecarboxamide 7 chloro 4 (dimethylamino) 1,4,4a,5,5a,6,11,12a octahydro 3,6,10,12,12a pentahydroxy 1,11 dioxo (4S (4alpha,4aalpha,5aalpha,6beta,12aalpha)), 7 Chloro 4 (dimethylamino) 1,4,4a,5,5a,6,11,12a octahydro 3,6,10,12,12a pentahydroxy 1,11 dioxo 2 naphthacenecarboxamide, DEMECLOCYCLINE, Demeclocycline (product), Demeclocycline (substance), DEMECLOCYCLINE PREPARATION, Demethylchlortetracycline, Brand name/Declomycin (Demeclocycline), Britain-BNF/Ledermycin (Demeclocycline)

Treatment

Drug Dosage

DRUG/Dose 300 mgm (Unit/Pill/Capsule size)

DRUG/Dose 600 mgm (Unit/Pill/Capsule size)

DRUG/Dose BID Medication

Definition

Tetracycline antibiotic drug

(Edit)

External Links Related to Demeclocycline (Declomycin) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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